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Genome-wide mosaicism within Mycobacterium abscessus: evolutionary and epidemiological implications

Sapriel G 1 , Konjek J 2 , Orgeur M 3 , Bouri L 4 , Frézal L 5 , Roux AL 6 Show all authors , Dumas E 7 , Brosch R 8 , Bouchier C 9 , Brisse S 10 , Vandenbogaert M 11 , Thiberge JM 12 , Caro V 13 , Ngeow YF 14 , Tan JL 15 , Herrmann JL 16 , Gaillard JL 17 , Heym B 18 , Wirth T 19

Affiliations 

  • 1 EA3647-EPIM, UFR des Sciences de La Santé, Université de Versailles St. Quentin, Montigny le Bretonneux, France. guillaume.sapriel@uvsq.fr
  • 2 EA3647-EPIM, UFR des Sciences de La Santé, Université de Versailles St. Quentin, Montigny le Bretonneux, France. konjek.julie@gmail.com
  • 3 Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, Paris, France. orgeur@molgen.mpg.de
  • 4 EA3647-EPIM, UFR des Sciences de La Santé, Université de Versailles St. Quentin, Montigny le Bretonneux, France. laurent.bouri@ens.uvsq.fr
  • 5 Institut of Biology of the Ecole Normale Supérieure, 46 rue d'Ulm, 75230, Paris, Cedex 05, France. frezal@biologie.ens.fr
  • 6 PF1-Plate-Forme Génomique, Institut Pasteur, Paris, France. anne-laure.roux@rpc.aphp.fr
  • 7 EA3647-EPIM, UFR des Sciences de La Santé, Université de Versailles St. Quentin, Montigny le Bretonneux, France. emilie.dumas26@gmail.com
  • 8 Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, Paris, France. roland.brosch@pasteur.fr
  • 9 PF1-Plate-Forme Génomique, Institut Pasteur, Paris, France. bouchier@pasteur.fr
  • 10 Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France. sbrisse@pasteur.fr
  • 11 Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France. mathias.vandenbogaert@pasteur.fr
  • 12 Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France. jean-michel.thiberge@pasteur.fr
  • 13 Institut Pasteur, Genotyping of Pathogens and Public Health, Paris, France. valerie.caro@pasteur.fr
  • 14 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. yunngeow@yahoo.com
  • 15 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. tjl2309@hotmail.com
  • 16 EA3647-EPIM, UFR des Sciences de La Santé, Université de Versailles St. Quentin, Montigny le Bretonneux, France. jean-louis.herrmann@rpc.aphp.fr
  • 17 EA3647-EPIM, UFR des Sciences de La Santé, Université de Versailles St. Quentin, Montigny le Bretonneux, France. jean-louis.gaillard@apr.aphp.fr
  • 18 EA3647-EPIM, UFR des Sciences de La Santé, Université de Versailles St. Quentin, Montigny le Bretonneux, France. beate.heym@apr.aphp.fr
  • 19 Laboratoire de Biologie intégrative des populations, Evolution moléculaire, Ecole Pratique des Hautes Etudes, Paris, France. wirth@mnhn.fr
BMC Genomics, 2016 Feb 17;17:118.
PMID: 26884275 DOI: 10.1186/s12864-016-2448-1

Abstract

In mycobacteria, conjugation differs from the canonical Hfr model, but is still poorly understood. Here, we quantified this evolutionary processe in a natural mycobacterial population, taking advantage of a large clinical strain collection of the emerging pathogen Mycobacterium abscessus (MAB).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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