• 1 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur, Malaysia
J Nat Prod, 2011 Dec 27;74(12):2556-62.
PMID: 22148233 DOI: 10.1021/np200730j


Four new linearly fused bisindole alkaloids, lumutinines A-D (1-4), were isolated from the stem-bark extract of Alstonia macrophylla. Lumutinines A (1) and B (2) represent the first examples of linear, ring A/F-fused macroline-macroline-type bisindoles, while lumutinines C (3) and D (4) were constituted from the union of macroline and sarpagine moieties. A reinvestigation of the stereochemical assignment of alstoumerine (8) by NMR and X-ray diffraction analyses indicated that the configuration at C-16 and C-19 required revision.

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