Display of the antigenic region of Nipah virus nucleocapsid protein on hepatitis B virus capsid

Yap WB 1 , Tey BT , Alitheen NB , Tan WS

Affiliations 

  • 1 Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
J Biosci Bioeng, 2012 Jan;113(1):26-9.
PMID: 22024533 DOI: 10.1016/j.jbiosc.2011.09.007

Abstract

The C-terminal domain of Nipah virus (NiV) nucleocapsid protein (NP₄₀₁₋₅₃₂) was inserted at the N-terminus and the immunodominant loop of hepatitis B core antigen (HBc). The stability of NP₄₀₁₋₅₃₂ increased tremendously when displayed on the HBc particles. These particles reacted specifically with the swine anti-NiV and the human anti-HBc antisera.

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