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A SPION-eicosane protective coating for water soluble capsules: Evidence for on-demand drug release triggered by magnetic hyperthermia

Che Rose L 1 , Bear JC 2 , McNaughter PD 1 , Southern P 3 , Piggott RB 4 , Parkin IP 2 Show all authors , Qi S 5 , Mayes AG 1

Affiliations 

  • 1 School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
  • 2 Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK
  • 3 UCL Healthcare Biomagnetics Laboratories, Royal Institution of Great Britain, 21 Albemarle Street, London, W1S 4BS, UK
  • 4 Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, UK
  • 5 School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK
Sci Rep, 2016;6:20271.
PMID: 26842884 DOI: 10.1038/srep20271

Abstract

An orally-administered system for targeted, on-demand drug delivery to the gastrointestinal (GI) tract is highly desirable due to the high instances of diseases of that organ system and harsh mechanical and physical conditions any such system has to endure. To that end, we present an iron oxide nanoparticle/wax composite capsule coating using magnetic hyperthermia as a release trigger. The coating is synthesised using a simple dip-coating process from pharmaceutically approved materials using a gelatin drug capsule as a template. We show that the coating is impervious to chemical conditions within the GI tract and is completely melted within two minutes when exposed to an RF magnetic field under biologically-relevant conditions. The overall simplicity of action, durability and non-toxic and inexpensive nature of our system demonstrated herein are key for successful drug delivery systems.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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