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A Sustainable Approach to the Stereoselective Synthesis of Diazaheptacyclic Cage Systems Based on a Multicomponent Strategy in an Ionic Liquid

Suresh Kumar R 1 , Almansour AI 2 , Arumugam N 3 , Altaf M 4 , Menéndez JC 5 , Kumar RR 6 Show all authors , Osman H 7

Affiliations 

  • 1 Department of Chemistry, College of Science, King Saud University P. O. Box 2455, Riyadh 11451, Saudi Arabia. rajusures@gmail.com
  • 2 Department of Chemistry, College of Science, King Saud University P. O. Box 2455, Riyadh 11451, Saudi Arabia. almansor@ksu.edu.sa
  • 3 Department of Chemistry, College of Science, King Saud University P. O. Box 2455, Riyadh 11451, Saudi Arabia. anatarajan@ksu.edu.sa
  • 4 Central Laboratory, College of Science, King Saud University P. O. Box 2455, Riyadh 11451, Saudi Arabia. altafamu@gmail.com
  • 5 Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, Madrid 28040, Spain. josecm@farm.ucm.es
  • 6 Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India. raju.ranjithkumar@gmail.com
  • 7 School of Chemical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia. ohasnah@usm.my
Molecules, 2016 Jan 29;21(2):165.
PMID: 26840282 DOI: 10.3390/molecules21020165

Abstract

The microwave-assisted three-component reactions of 3,5-bis(E)-arylmethylidene]tetrahydro-4(1H)-pyridinones, acenaphthenequinone and cyclic α-amino acids in an ionic liquid, 1-butyl-3-methylimidazolium bromide, occurred through a domino sequence affording structurally intriguing diazaheptacyclic cage-like compounds in excellent yields.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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