Affiliations 

  • 1 Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 2 Nanotechnology & Catalysis Research Centre (NANOCAT), IPS Building, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address: samira_bagheri@edu.um.my
Mater Sci Eng C Mater Biol Appl, 2016 Apr 1;61:906-21.
PMID: 26838922 DOI: 10.1016/j.msec.2015.12.094

Abstract

The actual in vivo tissue scaffold offers a three-dimensional (3D) structural support along with a nano-textured surfaces consist of a fibrous network in order to deliver cell adhesion and signaling. A scaffold is required, until the tissue is entirely regenerated or restored, to act as a temporary ingrowth template for cell proliferation and extracellular matrix (ECM) deposition. This review depicts some of the most significant three dimensional structure materials used as scaffolds in various tissue engineering application fields currently being employed to mimic in vivo features. Accordingly, some of the researchers' attempts have envisioned utilizing graphene for the fabrication of porous and flexible 3D scaffolds. The main focus of this paper is to evaluate the topographical and topological optimization of scaffolds for tissue engineering applications in order to improve scaffolds' mechanical performances.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.