Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide-deficient rats

Jaffri JM 1 , Mohamed S , Rohimi N , Ahmad IN , Noordin MM , Manap YA

Affiliations 

  • 1 Institute of BioScience and Faculties, University of Putra Malaysia, Serdang, Selangor, Malaysia
J Med Food, 2011 Jul-Aug;14(7-8):775-83.
PMID: 21631357 DOI: 10.1089/jmf.2010.1170

Abstract

Oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation and antioxidant properties. This study evaluated the catechin-rich OPLE antioxidant, antihypertensive, and cardiovascular effects in normal and nitric oxide (NO)-deficient hypertensive rats. OPLE was administered orally (500 mg/kg of body weight/day) to normotensive Wistar rats and N(ω)-nitro-L-arginine methyl ester (L-NAME)-induced NO-deficient hypertensive rats. OPLE significantly (P

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