Synthesis and discovery of novel hexacyclic cage compounds as inhibitors of acetylcholinesterase

Suresh Kumar R 1 , Ashraf Ali M , Osman H , Ismail R , Choon TS , Yoon YK Show all authors , Wei AC , Pandian S , Manogaran E

Affiliations 

  • 1 School of Chemical Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia
Bioorg Med Chem Lett, 2011 Jul 1;21(13):3997-4000.
PMID: 21621414 DOI: 10.1016/j.bmcl.2011.05.003

Abstract

Hexacyclic derivatives share vital pharmacological properties, considered useful in Alzheimer's disease. The aim of this study was synthesis and its evaluation for acetyl cholinesterase inhibitory activity of novel hexacyclic analogues. Compound 4f, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.72 μmol/L.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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