Polymeric behavior evaluation of PVP K30-poloxamer binary carrier for solid dispersed nisoldipine by experimental design

Kyaw Oo M 1 , Mandal UK 1 , Chatterjee B 1

Affiliations 

  • 1 a Department of Pharmaceutical Technology , Kulliyyah of Pharmacy, International Islamic University Malaysia , Kuantan , Malaysia
Pharm Dev Technol, 2017 Feb;22(1):2-12.
PMID: 26616399 DOI: 10.3109/10837450.2015.1116568

Abstract

High melting point polymeric carrier without plasticizer is unacceptable for solid dispersion (SD) by melting method. Combined polymer-plasticizer carrier significantly affects drug solubility and tableting property of SD.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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