Dinuclear Gold(I) Pyrrolidinedithiocarbamato Complex: Cytotoxic and Antimigratory Activities on Cancer Cells and the Use of Metal-Organic Framework

Sun RW 1 , Zhang M 2 , Li D 3 , Zhang ZF 2 , Cai H 2 , Li M 2 Show all authors , Xian YJ 2 , Ng SW 4 , Wong AS 5

Affiliations 

  • 1 Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China). rwysun@stu.edu.cn
  • 2 Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China)
  • 3 Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province, Shantou University, 243 Da Xue Road, Shantou, Guangdong 515063 (P. R. China). dli@stu.edu.cn
  • 4 Department of Chemistry, University of Malaya, 50603 Kuala Lumpur (Malaysia)
  • 5 School of Biological Sciences, The University of Hong Kong, Pokfulam, Hong Kong (P. R. China)
Chemistry, 2015 Dec 14;21(51):18534-8.
PMID: 26459298 DOI: 10.1002/chem.201503656

Abstract

A dinuclear gold(I) pyrrolidinedithiocarbamato complex (1) with a bidentate carbene ligand has been constructed and shows potent in vitro cytotoxic activities towards cisplatin-resistant ovarian cancer cells A2780cis. Its rigid scaffold enables a zinc(II)-based metal-organic framework (Zn-MOF) to be used as a carrier in facilitating the uptake and release of 1 in solutions. Instead of using a conventional dialysis approach for the drug-release testing, in this study, a set of transwell assay-based experiments have been designed and employed to examine the cytotoxic and antimigratory activities of 1@Zn-MOF towards A2780cis.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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