MyMedR

Displaying publications 1 - 20 of 70 in total

Abstract:

Sort:

Corrigendum: A study of the factors influencing HIV-preventive intentions among "hookup" application users

Li M, Li N

Front Psychol, 2023;14:1166258.
PMID: 36925589 DOI: 10.3389/fpsyg.2023.1166258

[This corrects the article DOI: 10.3389/fpsyg.2022.1048226.].
Fulltext A study of the factors influencing HIV-preventive intentions among "hookup" application users

Li M, Li N

Front Psychol, 2022;13:1048226.
PMID: 36687841 DOI: 10.3389/fpsyg.2022.1048226

"Hooking up" refers to the act of experiencing sexual intimacy with strangers without committing to a romantic relationship. Social media provide more convenient conditions for hooking up; however, it also poses a greater risk for HIV infection. Therefore, it is necessary to study the factors influencing the HIV-preventive intentions of those who engage in online dating to devise effective strategies for preventing the spread of HIV. This study consisted of a questionnaire that was distributed to 520 users of the Hello Group application. The survey results revealed that structural equation modeling is a useful framework for understanding the risk of HIV transmission in casual hookup encounters. In addition, combining the health belief model with the theory of planned behavior can provide recommendations for enhancing HIV-preventive intentions among users of dating applications. The results showed that mindfulness, the Chinese cultural context, perceived benefits, and self-efficacy were the main predictors of users' HIV-preventive intentions when using online dating applications. Among the perceived HIV risks, only perceived barriers had a negative effect on users' HIV-preventive intentions. In addition, attitude, subjective norms, and behavior control served as mediating variables between independent variables and HIV-preventive intentions; however, the mediating effect of attitude on perceived benefits and intentions was not significant. According to our study, some users misunderstand the risks and make incorrect assessments of the cultural risks of hooking up. Therefore, it is necessary to pay attention to the research on the psychological tendencies of users and risk intervention when studying the concept of hooking up.
Fulltext Dialectical materialism and teaching by words and deeds applied to the education of clinical medical students

Li M, Sorayyaei Azar A

Front Med (Lausanne), 2023;10:1037101.
PMID: 37559929 DOI: 10.3389/fmed.2023.1037101
Rapid developing basaloid squamous cell carcinoma of the uterine cervix in a young adult Taiwanese

Tsai HJ, Liou B, Li MC

Malays J Pathol, 2013 Dec;35(2):177-80.
PMID: 24362481

Basaloid squamous cell carcinoma (BSCC) of the uterine cervix is a rare malignancy of the female genital tract with a poorer clinical outcome than SCC of the uterine cervix. We report a case of BSCC of the uterine cervix developing rapidly in a young adult Taiwanese. A 35-year-old woman, Para 2, visited the emergency room with severe dizziness, palpitations and sudden excessive vaginal bleeding with hemoglobin of 3.6 g/dl. She had been well and healthy but intermittent vaginal spotting developed for around 6 months previously and was treated as abnormal uterine bleeding by ob-gyn practitioners. She had a repeat cesarean operation 16 months prior to this episode and the last Pap smear showed reactive change 12 months ago at our hospital. On examination, she had an ulcerated, necrotic, and punched-out lesion of 5 cm of the cervix. A cervical biopsy revealed poorly differentiated typical BSCC. Abdominal/pelvic computerized tomography and whole body positron emission tomography confirmed FIGO staging IB2. She responded well to concurrent chemoradiotherapy. Follow-up for the patient is ongoing. This is a rapid developing BSCC of the uterine cervix, although we cannot actually ascertain when it started and how rapidly it progressed.
Inducible transgene expression in undifferentiated mouse embryonic stem cells and embryoid bodies

Nordin N, Nathan S, Li M, Mason JO

Med J Malaysia, 2008 Jul;63 Suppl A:59-60.
PMID: 19024983

Obtaining pure population of neural cells from embryonic stem (ES) cells remains a challenge as little is known about the genes that govern embryonic stem cell differentiation. Using mouse ES cells, we aim to uncover the mechanisms that regulate neural differentiation of ES cells by focusing on roles played by Wnt family genes. Combining two techniques, Cre/loxP-based genetic recombination and ligand-dependent activation of Cre, we have generated transgenic ES cell lines that allow for the temporal control of expression and activity of Wnt gene (Wnt1-Ha) and Wnt antagonist (Dkk1). The ability of these cell lines in inducing the expression of transgene in undifferentiated ES cells and, more importantly, in differentiated derivatives of ES cells in vitro is evaluated.
Fulltext Motivations Influencing Alipay Users to Participate in the Ant Forest Campaign: An Empirical Study

Wang S, Ibrahiem MH, Li M

Int J Environ Res Public Health, 2022 Dec 18;19(24).
PMID: 36554915 DOI: 10.3390/ijerph192417034

As one of the largest payment platforms in China, Alipay, launched a green behavior project called Ant Forest. The purpose of taking this initiative by Alipay is to make the world greener. This mobile application has motivated many users to plant millions of trees. However, minimal studies have been conducted to empirically disclose the factors that motivate Alipay users to participate in Ant Forest. A mixed-method approach is used to examine the factors influencing Alipay users to participate in Ant Forest and the level of satisfaction they got from it. The qualitative method was carried out through a structured questionnaire from 400 Alipay users and qualitative data from 20 users who have applied to Ant Forest and successfully planted trees. Additionally, alongside the mixed method employed to rationalize the relationship highlighted, a multiple regression model was employed to predict the value of a dependent variable (level of satisfaction) based on the value of several independent variables (namely, number of years engaged with Ant Forest activities, age, gender, profession, and education). The empirical results show that intrinsic motivations (enjoyment, social interaction, fulfilment, altruism) and extrinsic motivations (external rewards, competition) influence Alipay users to participate in the Ant Forest project. Further insights are presented in the concluding section for all stakeholders for environmental sustainability among the users of Alipay.
Fulltext Socio-economic factors are the main factors affecting organ donation

Li M, Li H, Azar AS

Rev Assoc Med Bras (1992), 2023;69(10):e20230940.
PMID: 37820179 DOI: 10.1590/1806-9282.20230940
The impact of a modified ileal neobladder on the lifestyle and voiding patterns in Asian patients

Lee KT, Li MK, Cheng WS, Foo KT

Br J Urol, 1998 May;81(5):705-8.
PMID: 9634045 DOI: 10.1046/j.1464-410x.1998.00586.x

OBJECTIVE: To evaluate the impact of the modified ileal neobladder reconstruction on lifestyle, voiding habits and functional outcome in Asian patients.

PATIENTS AND METHODS: Twenty-seven Asian patients (25 men and two women, mean age 59 years, range 41-76) underwent modified ileal neobladder reconstruction after radical cystectomy for carcinoma of the bladder. The mean (range) follow-up was 21 (3-75) months. All patients were evaluated retrospectively using case notes, reviews, interviews and voiding charts; 18 patients underwent urodynamic studies.

RESULT: Twenty-five patients (93%) achieved diurnal and 23 (85%) nocturnal continence within 6 months. Of the 19 patients who were in employment before surgery, 15 continued to be economically active afterward; 26 patients (96%) reported no change in their daily living activities. Of 16 men who reported being potent pre-operatively only four retained some residual erectile function. Twenty-three patients were interviewed about their voiding habits and satisfaction with the outcome of surgery. Fourteen patients had no sensation of reservoir fullness and of the 21 men, 13 had to squat or sit to void effectively. The mean (range) voiding frequency was 5 (4-8) during the day and 2 (0-4) during sleep. Twenty-two patients were satisfied with the overall outcome.

CONCLUSIONS: The modified ileal bladder provides a high urinary continence rate with minimal changes in daily living activities and occupational status. The functional outcome was very satisfactory and accepted well, despite some changes in reservoir sensation, voiding posture and erectile function. The method is a viable option for reconstruction after cystectomy in Asian patients.
An effective temperature compensation approach for ultrasonic hydrogen sensors

Tan X, Li M, Arsad N, Wen X, Lu H

Rev Sci Instrum, 2018 Mar;89(3):035005.
PMID: 29604764 DOI: 10.1063/1.5017639

Hydrogen is a kind of promising clean energy resource with a wide application prospect, which will, however, cause a serious security issue upon the leakage of hydrogen gas. The measurement of its concentration is of great significance. In a traditional approach of ultrasonic hydrogen sensing, a temperature drift of 0.1 °C results in a concentration error of about 250 ppm, which is intolerable for trace amount of gas sensing. In order to eliminate the influence brought by temperature drift, we propose a feasible approach named as linear compensation algorithm, which utilizes the linear relationship between the pulse count and temperature to compensate for the pulse count error (ΔN) caused by temperature drift. Experimental results demonstrate that our proposed approach is capable of improving the measurement accuracy and can easily detect sub-100 ppm of hydrogen concentration under variable temperature conditions.
Fulltext Editorial: The genetics of human Mendelian skin disorders

Yap WH, Zhang J, Li M, Guo Y

Front Genet, 2022;13:1061724.
PMID: 36531233 DOI: 10.3389/fgene.2022.1061724
Regulatory actions of 3',5'-cyclic adenosine monophosphate on osteoclast function: possible roles of Epac-mediated signaling

Jeevaratnam K, Salvage SC, Li M, Huang CL

Ann N Y Acad Sci, 2018 Dec;1433(1):18-28.
PMID: 29846007 DOI: 10.1111/nyas.13861

Alterations in cellular levels of the second messenger 3',5'-cyclic adenosine monophosphate ([cAMP]i ) regulate a wide range of physiologically important cellular signaling processes in numerous cell types. Osteoclasts are terminally differentiated, multinucleated cells specialized for bone resorption. Their systemic regulator, calcitonin, triggers morphometrically and pharmacologically distinct retraction (R) and quiescence (Q) effects on cell-spread area and protrusion-retraction motility, respectively, paralleling its inhibition of bone resorption. Q effects were reproduced by cholera toxin-mediated Gs -protein activation known to increase [cAMP]i , unaccompanied by the [Ca2+ ]i changes contrastingly associated with R effects. We explore a hypothesis implicating cAMP signaling involving guanine nucleotide-exchange activation of the small GTPase Ras-proximate-1 (Rap1) by exchange proteins directly activated by cAMP (Epac). Rap1 activates integrin clustering, cell adhesion to bone matrix, associated cytoskeletal modifications and signaling processes, and transmembrane transduction functions. Epac activation enhanced, whereas Epac inhibition or shRNA-mediated knockdown compromised, the appearance of markers for osteoclast differentiation and motility following stimulation by receptor activator of nuclear factor kappa-Β ligand (RANKL). Deficiencies in talin and Rap1 compromised in vivo bone resorption, producing osteopetrotic phenotypes in genetically modified murine models. Translational implications of an Epac-Rap1 signaling hypothesis in relationship to N-bisphosphonate actions on prenylation and membrane localization of small GTPases are discussed.
Ecological footprints and sustainable environmental management: A critical view of China's economy

Li M, Badeeb RA, Dogan E, Gu X, Zhang H

J Environ Manage, 2023 Dec 01;347:118994.
PMID: 37722155 DOI: 10.1016/j.jenvman.2023.118994

Global economies have recently been concerned about sustainable environmental management by reducing emissions and tackling ecological footprints. The rapid economic expansion and investment in traditional manufacturing further raises environmental degradation. China surpasses other emerging economies in the economic growth race yet has remained the top pollution-emitting economy for the last few decades, necessitating scholarly attention. This study examines the influencing factors of ecological footprints in China from the perspective of COP27. Using the extended dataset from 1988 to 2021, this study uses several time series diagnostic tests and verifies the existence of the long-run association between the study variables. Consequently, the non-linear scattered data leads to non-parametric (method of moment quantile regression) adoption. The empirical results indicate that only economic growth is a significant factor in environmental quality degradation in China. However, improving renewable energy usage, research and development, and foreign direct investment reduces the country's ecological footprint. Hence, the latter variables substantially lead to environmental sustainability. The robustness of the results is confirmed via a robust non-parametric estimator and causality test. Based on the empirical results, this study recommends increased investment in research and development, renewable production, and foreign direct investment enhancement.
PCR tools for the verification of the specific identity of ascaridoid nematodes from dogs and cats

Li MW, Lin RQ, Chen HH, Sani RA, Song HQ, Zhu XQ

Mol Cell Probes, 2007 Oct-Dec;21(5-6):349-54.
PMID: 17532185

Based on the sequences of the internal transcribed spacers (ITS-1 and ITS-2) of nuclear ribosomal DNA (rDNA) of Toxocara canis, Toxocara cati, Toxocara malaysiensis and Toxascaris leonina, specific forward primers were designed in the ITS-1 or ITS-2 for each of the four ascaridoid species of dogs and cats. These primers were used individually together with a conserved primer in the large subunit of rDNA to amplify partial ITS-1 and/or ITS-2 of rDNA from 107 DNA samples from ascaridoids from dogs and cats in China, Australia, Malaysia, England and the Netherlands. This approach allowed their specific identification, with no amplicons being amplified from heterogeneous DNA samples, and sequencing confirmed the identity of the sequences amplified. The minimum amounts of DNA detectable using the PCR assays were 0.13-0.54ng. These PCR assays should provide useful tools for the diagnosis and molecular epidemiological investigations of toxocariasis in humans and animals.
Chiroptical Activity from an Achiral Biological Metal-Organic Framework

Xu LL, Zhang HF, Li M, Ng SW, Feng JH, Mao JG, et al.

J Am Chem Soc, 2018 09 19;140(37):11569-11572.
PMID: 30141923 DOI: 10.1021/jacs.8b06725

Chiroptical activity is observed from an achiral adenine-containing metal-organic framework (MOF) named ZnFDCA. Such a seemingly counterintuitive phenomenon can, in fact, be predicted by the intrinsic crystal symmetry of 4̅2 m point group. Although theoretically allowed, examples of optically active achiral crystals are extremely rare. ZnFDCA is the first reported achiral MOF showing optical activity, as demonstrated by a pair of circular dichroism signals with opposite signs and enhanced intensity. Moreover, simply through adding an amino substituent to adenine, the chiroptical activity, as well as nonlinear optical activity, of the analogous MOF, namely ZnFDCA-NH2, disappears due to diverse packing pattern giving rise to centrosymmetric crystal symmetry.
A luminescent edge-interlocked prismatic heteroleptic metallocage assembled through a ligand replacement reaction

Zhan SZ, Li JH, Zhang GH, Liu XW, Li M, Zheng J, et al.

Chem Commun (Camb), 2019 Oct 03;55(80):11992-11995.
PMID: 31498358 DOI: 10.1039/c9cc05236d

A luminescent edge-interlocked heteroleptic metallocage based on Cu3(pyrazolate)3 was prepared through a ligand replacement reaction from a homoleptic metallocage and a new ligand. Its structure was confirmed by XRD and MALDI-TOF mass spectrometry. Theoretical calculations revealed the new ligand was evidently responsible for the bathochromic shift of the optimal excitation. This work provides a heteroleptic strategy to regulate the interlocking fashion and photophysical mechanism of metallocages based on Cu3(pyrazolate)3.
Fulltext Underwater Object Detection and Reconstruction Based on Active Single-Pixel Imaging and Super-Resolution Convolutional Neural Network

Li M, Mathai A, Lau SLH, Yam JW, Xu X, Wang X

Sensors (Basel), 2021 Jan 05;21(1).
PMID: 33466530 DOI: 10.3390/s21010313

Due to medium scattering, absorption, and complex light interactions, capturing objects from the underwater environment has always been a difficult task. Single-pixel imaging (SPI) is an efficient imaging approach that can obtain spatial object information under low-light conditions. In this paper, we propose a single-pixel object inspection system for the underwater environment based on compressive sensing super-resolution convolutional neural network (CS-SRCNN). With the CS-SRCNN algorithm, image reconstruction can be achieved with 30% of the total pixels in the image. We also investigate the impact of compression ratios on underwater object SPI reconstruction performance. In addition, we analyzed the effect of peak signal to noise ratio (PSNR) and structural similarity index (SSIM) to determine the image quality of the reconstructed image. Our work is compared to the SPI system and SRCNN method to demonstrate its efficiency in capturing object results from an underwater environment. The PSNR and SSIM of the proposed method have increased to 35.44% and 73.07%, respectively. This work provides new insight into SPI applications and creates a better alternative for underwater optical object imaging to achieve good quality.
Effective passivation of lead by phosphate solubilizing bacteria capsules containing tricalcium phosphate

Zhang K, Teng Z, Shao W, Wang Y, Li M, Lam SS

J Hazard Mater, 2020 10 05;397:122754.
PMID: 32361140 DOI: 10.1016/j.jhazmat.2020.122754

Phosphate solubilizing bacteria (PSBs) shows high potential to be used for lead passivation in sediments due to the abilities of releasing phosphate and the subsequent formation of insoluble Pb-phosphate compounds. In this research, microbial capsules implemented with sodium alginate and CaCl2, containing Leclercia adecarboxylata L15 (a lead resistant PSB) and Ca3(PO4)2, were developed and the performance on lead passivation under different conditions was examined. The optimal concentrations of sodium alginate and CaCl2 for formulating the capsules were determined to be 0.3% and 10%, respectively. The removal efficiency of Pb2+ by capsules containing L15 and Ca3(PO4)2 was up to 98% with a capsule dosage of 2%, initial Pb2+ concentration of 1mM and pH of 3.0, which was better than that of free L15 (18%) and capsules containing only L15 (34%). Lead was immobilized via the formation of Pb5(PO4)3Cl on the surface and Pb3(PO4)2 in the interior of the capsules. The simulated sediment remediation experiments showed that the acid soluble fraction of lead reduced from 28% to 14% and transformed into more stable fractions after 10 days. The experiment results indicated that PSBs capsules coupled with phosphate materials have a great promise for application in remediation of lead contaminated sediments.
Fulltext Unlocking Access To Novel Medicines In China-A Review From A Health System Perspective

Diao Y, Li M, Huang Z, Sun J, Chee YL, Liu Y

Risk Manag Healthc Policy, 2019;12:357-367.
PMID: 31908552 DOI: 10.2147/RMHP.S226379

China's healthcare reform aims to provide affordable and equitable basic healthcare for all by 2020. Access to medicines is an essential part of the healthcare. The efforts of promoting access to medicines have been moving from meeting the needs of the basic healthcare, towards increasingly dedicated resources to offer breakthrough therapies. Looking at access to novel medicines from a health system perspective, and placing the changes China has made into that system context, this paper makes a comprehensive review of the progress of access to novel medicines in China. The review drew on two sources of information, which included desk review of published and grey literature, and key informant interview. Five hurdles were identified which create barriers of access to novel medicines, ranging from regulation and financing of medicines, intellectually property rights protection, and development of innovation capacity, to other health system components. Multiple policies have been implementing in China to remove the multiple access barriers gradually. Universal access to medicines has been moving from towards the basic common conditions to the world breakthrough technologies. We see cause for optimism, but recognize that there is a long way to go. Achieving broader and better access to modern medicines for Chinese patients will require multiple and coordinated government efforts, which would need to target the whole lifecycle regulation of novel medicines with a health system perspective, from balancing IP protection, strengthening R&D and public health, to appropriate regulatory approach and financing mechanism, and to supply chain management, as well as smart use.
Traditional uses, phytochemistry, pharmacology and toxicology of the genus Gynura (Compositae): A comprehensive review

Meng X, Li J, Li M, Wang H, Ren B, Chen J, et al.

J Ethnopharmacol, 2021 Aug 10;276:114145.
PMID: 33932518 DOI: 10.1016/j.jep.2021.114145

ETHNOPHARMACOLOGICAL RELEVANCE: Gynura cass., belonging to the tribe Senecoineae of the family Compositae, contains more than 40 accepted species as annual or perennial herbs, mainly distributed in Asia, Africa and Australia. Among them, 11 species are distributed in China. Many of the Gynura species have been used as traditional herbal medicines for the treatment of diabetes mellitus, rheumatism, eruptive fever, gastric ulcer, bleeding, abscesses, bruises, burning pains, rashes and herpes zoster infection in tropical Asia countries such as China, Thailand, Indonesia, Malaysia, and Vietnam. Some of the species have been used as vegetables, tea beverage or ornamental plants by the local people.
AIM OF THE STUDY: A more comprehensive and in-depth review about the geographical distribution, traditional uses, chemical constituents and pharmacological activities as well as safe and toxicity of Gynura species has been summarized, hoping to provide a scientific basis for rational development and utilization as well as to foster further research of these important medicinal plant resources in the future.
MATERIALS AND METHODS: A review of the literature was performed based on the existing peer-reviewed researches by consulting scientific databases including Web of Science, PubMed, Elsevier, Google Scholar, SciFinder and China National Knowledge Infrastructure.
RESULTS: Many of the Gynura species have been phytochemically studied, which led to the isolation of more than 338 compounds including phenolics, flavonoids, alkaloids, terpenoids, steroids, cerebrosides, aliphatics and other compounds. Pharmacological studies in vitro and in vivo have also confirmed the various bioactive potentials of extracts or pure compounds from many Gynura plants, based on their claimed ethnomedicinal and anecdotal uses, including antioxidant, anti-inflammation, anticancer, antidiabetic, antihypertension, antibacterial and other activities. However, pyrrolizidine alkaloids (PAs) pose a threat to the medication safety and edible security of Gynura plants because of toxicity issues, requiring the need to pay great attention to this phenomenon.
CONCLUSION: The traditional uses, phytochemistry and pharmacology of Gynura species described in this review demonstrated that these plants contain a great number of active constituents and display a diversity of pharmacological activities. However, the mechanism of action, structure-activity relationship, potential synergistic effects and pharmacokinetics of these components need to be further elucidated. Moreover, further detailed research is urgently needed to explain the mechanisms of toxicity induced by PAs. In this respect, effective detoxification strategies need to be worked out, so as to support the safe and reasonable utilization of Gynura plant resources in the future.
Tai chi improves depressive symptoms among community-dwelling older persons by mediating BDNF methylation: A preliminary study

Liao S, Tan M, Li M, Ren J, Wang Y, Zheng R, et al.

Geriatr Nurs, 2022 Feb 10;44:137-142.
PMID: 35152066 DOI: 10.1016/j.gerinurse.2022.01.015

Tai Chi could alleviate depression, while the biological mechanisms underlying this effect remains unelucidated. This study recruited 18 community-dwelling older persons with a pre-post testing design, aiming to unveil the potential epigenetic effect by which Tai Chi in the alleviation of depression, using methylation of BDNF promoter as the biomarker. The methylation levels (determined by pyrosequencing using saliva samples) of the targeted BDNF sequence were positively associated with the existence and severity of depressive symptoms (measured with the 9-item Patient Health Questionnaire). Both methylation levels and depression decreased significantly after the Tai Chi intervention. Demethylation of BDNF promoter might be one of the potential mechanisms underlying the holistic depression alleviating effect of Tai Chi. BDNF methylation may potentially serve as a screening, diagnostic as well as disease activity biomarker to determine treatment effects for depression. Further adequately powered studies are needed to verify and strengthen our findings.

Filters

Please provide feedback to Administrator (afdal@afpm.org.my)

External Links