Affiliations 

  • 1 Department of Biomedical Engineering, Faculty of Engineering Building, University of Malaya, Kuala Lumpur, 50603, Malaysia
  • 2 Department of Orthopedic Surgery, Faculty of Medicine Building, University of Malaya, Kuala Lumpur, 50603, Malaysia
  • 3 Department of Surgery, Faculty of Medicine Building, University of Malaya, Kuala Lumpur, 50603, Malaysia
J Biomed Mater Res A, 2016 Jan;104(1):245-56.
PMID: 26362913 DOI: 10.1002/jbm.a.35561

Abstract

Extracellular matrices have drawn attention in tissue engineering as potential biomaterials for scaffold fabrication because of their bioactive components. Noninvasive techniques of scaffold fabrication and cross-linking treatments are believed to maintain the integrity of bioactive molecules while providing proper architectural and mechanical properties. Cartilage matrix derived scaffolds are designed to support the maintenance of chondrocytes and provide proper signals for differentiation of chondroinducible cells. Chondroinductive potential of bovine articular cartilage matrix derived porous scaffolds on human dermal fibroblasts and the effect of scaffold shrinkage on chondrogenesis were investigated. An increase in sulfated glycosaminoglycans production along with upregulation of chondrogenic genes confirmed that physically treated cartilage matrix derived scaffolds have chondrogenic potential on human dermal fibroblasts.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.