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Antidiabetic and antioxidant activities of Nypa fruticans Wurmb. vinegar sample from Malaysia

Yusoff NA 1 , Yam MF 2 , Beh HK 2 , Abdul Razak KN 2 , Widyawati T 3 , Mahmud R 2 Show all authors , Ahmad M 2 , Asmawi MZ 2

Affiliations 

  • 1 School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia; Integrative Medicine Cluster, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Penang, Malaysia. Electronic address: noradlinyusoff@yahoo.com
  • 2 School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia
  • 3 School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia; Pharmacology Department, Medical Faculty, University of Sumatera Utara, 20155 Medan, Indonesia
Asian Pac J Trop Med, 2015 Aug;8(8):595-605.
PMID: 26321511 DOI: 10.1016/j.apjtm.2015.07.015

Abstract

OBJECTIVES: To study the antidiabetic and antioxidant activities of nipa palm vinegar (NPV) used in traditional Malay medicine for treating diabetes.

METHODS: NPV was extracted using liquid-liquid extraction method and the obtained samples were subjected to antidiabetic studies using normal and streptozotocin-induced diabetic rat models whereas antidoxidant activities were investigated via in vitro antioxidant tests namely 2,2-diphenyl-1-picrylhydrazyl and 2,2'-azinobis-3-ethylbenzothiozoline-6-sulfonic acid free radicals scavenging activities and the reducing power assay.

RESULTS: Single administration of NPV and its extracts were not effective in both normal and diabetic rats. In intraperitoneal glucose tolerance test, NPV and its aqueous extract showed significant blood glucose lowering effect. In the sub-acute study, compared with the diabetic control, aqueous extract of NPV showed the most notable blood glucose lowering effect (56.6%) and a significant improvement in serum insulin levels (79.8%, P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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