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ABO blood group alleles and prostate cancer risk: Results from the breast and prostate cancer cohort consortium (BPC3)

Markt SC 1 , Shui IM 1 , Unger RH 1 , Urun Y 2 , Berg CD 3 , Black A 4 Show all authors , Brennan P 5 , Bueno-de-Mesquita HB 6 , Gapstur SM 7 , Giovannucci E 1 , Haiman C 8 , Henderson B 8 , Hoover RN 5 , Hunter DJ 1 , Key TJ 9 , Khaw KT 10 , Canzian F 11 , Larranga N 12 , Le Marchand L 13 , Ma J 1 , Naccarati A 14 , Siddiq A 15 , Stampfer MJ 1 , Stattin P 16 , Stevens VL 17 , Stram DO 8 , Tjønneland A 18 , Travis RC 9 , Trichopoulos D 1 , Ziegler RG 5 , Lindstrom S 1 , Kraft P 1 , Mucci LA 1 , Choueiri TK 19 , Wilson KM 1

Affiliations 

  • 1 Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts
  • 2 Department of Medical Oncology, Ankara University Faculty of Medicine, Ankara, Turkey
  • 3 Department of Radiation Oncology, Johns Hopkins Medicine, Baltimore, Maryland
  • 4 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland
  • 5 International Agency for Research on Cancer, Lyon, France
  • 6 National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands
  • 7 Epidemiology Research Program, American Cancer Society, Atlanta, Georgia
  • 8 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
  • 9 Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
  • 10 School of Clinical Medicine, Cambridge Institute of Public Health, University of Cambridge, Cambridge, UK
  • 11 Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany
  • 12 Public Health Division of Gipuzkoa, BIODonostia Research Institute, Basque Health Department, Spain
  • 13 Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii
  • 14 HuGeF Foundation Molecular and Genetic Epidemiology Unit, Torino, Italy
  • 15 Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK
  • 16 Department of Surgery and Perioperative sciences, Urology and Andrology, Ume, å, University, Sweden
  • 17 Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts
  • 18 Danish Cancer Society Research Center, Copenhagen, Denmark
  • 19 Department of Genitourinary Oncology, Dana Farber Cancer Institute, Boston, Massachusetts
Prostate, 2015 Nov;75(15):1677-81.
PMID: 26268879 DOI: 10.1002/pros.23035

Abstract

BACKGROUND: ABO blood group has been associated with risk of cancers of the pancreas, stomach, ovary, kidney, and skin, but has not been evaluated in relation to risk of aggressive prostate cancer.

METHODS: We used three single nucleotide polymorphisms (SNPs) (rs8176746, rs505922, and rs8176704) to determine ABO genotype in 2,774 aggressive prostate cancer cases and 4,443 controls from the Breast and Prostate Cancer Cohort Consortium (BPC3). Unconditional logistic regression was used to calculate age and study-adjusted odds ratios and 95% confidence intervals for the association between blood type, genotype, and risk of aggressive prostate cancer (Gleason score ≥8 or locally advanced/metastatic disease (stage T3/T4/N1/M1).

RESULTS: We found no association between ABO blood type and risk of aggressive prostate cancer (Type A: OR = 0.97, 95%CI = 0.87-1.08; Type B: OR = 0.92, 95%CI =n0.77-1.09; Type AB: OR = 1.25, 95%CI = 0.98-1.59, compared to Type O, respectively). Similarly, there was no association between "dose" of A or B alleles and aggressive prostate cancer risk.

CONCLUSIONS: ABO blood type was not associated with risk of aggressive prostate cancer.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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