A total of 200 university students were surveyed to ascertain if gender, personality traits and social support were associated with self-esteem. There were equal numbers of males and females in the study, with controls for living and education status. The results showed that gender was not significantly associated with self-esteem. Whilst all the personality and social support factors were found to be associated with levels of self-esteem, only extraversion, openness to new experiences, conscientiousness, emotional stability and total amount of social support were found to predict self-esteem. Recommendations are made for early identification and interventions for populations at risk of low self-esteem based on the findings of the study.