Antibiotic susceptibility and molecular epidemiology of Panton-Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey

Macedo-Viñas M 1 , Conly J 2 , Francois P 3 , Aschbacher R 4 , Blanc DS 5 , Coombs G 6 Show all authors , Daikos G 7 , Dhawan B 8 , Empel J 9 , Etienne J 10 , Figueiredo AM 11 , George Golding Cnisp 12 , Han L 13 , Kim HB 14 , Köck R 15 , Larsen A 16 , Layer F 17 , Lo J 18 , Maeda T 19 , Mulvey M 12 , Pantosti A 20 , Saga T 19 , Schrenzel J 3 , Simor A 21 , Skov R 16 , Van Rijen M 22 , Wang H 23 , Zakaria Z 24 , Harbarth S 3

Affiliations 

  • 1 Hôpitaux Universitaires de Genève, Geneva, Switzerland. Electronic address: mmacedo@cenaque.org.uy
  • 2 Hôpitaux Universitaires de Genève, Geneva, Switzerland; University of Calgary, Calgary, Canada
  • 3 Hôpitaux Universitaires de Genève, Geneva, Switzerland
  • 4 Laboratorio Aziendale de Microbiologia e Virologia, Bolzano, Italy
  • 5 Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
  • 6 Curtin University, Perth, Australia
  • 7 Laiko General Hospital, Athens, Greece
  • 8 All India Institute of Medical Sciences, New Delhi, India
  • 9 National Medicine Institute (NMI), Warsaw, Poland
  • 10 National Reference Center for Staphylococci, Lyon, France
  • 11 Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • 12 National Microbiology Laboratory and Canadian Nosocomial Infection Surveillance Program (CNISP), Winnipeg, Canada
  • 13 Shanghai Ruijin Hospital, Shanghai, China
  • 14 Seoul National University, Bundang Hospital, Seongnam, South Korea
  • 15 University Hospital Münster, Münster, Germany
  • 16 Statens Serum Institut, Copenhagen, Denmark
  • 17 National Reference Centre for Staphylococci and Enterococci, Robert Koch Institute, Wernigerode, Germany
  • 18 Public Health Laboratory Services Branch Centre for Health Protection, Hong Kong Special Administrative Region
  • 19 Toho University Omori Hospital, Tokyo, Japan
  • 20 Instituto Superiore di Sanità, Rome, Italy
  • 21 Sunnybrook Health Sciences Centre, Toronto, Canada
  • 22 Laboratory for Microbiology and Infection Control, Breda, The Netherlands
  • 23 Peking Union Medical College Hospital, Beijing, China
  • 24 University Veterinary Hospital, Universiti Putra, Serdang, Malaysia
J Glob Antimicrob Resist, 2014 Mar;2(1):43-47.
PMID: 27873637 DOI: 10.1016/j.jgar.2013.08.003

Abstract

The antibiotic susceptibility and molecular epidemiology of Panton-Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) isolates reported from 17 countries in the Americas, Europe and, Australia-Asia were analysed. Among a total of 3236 non-duplicate isolates, the lowest susceptibility was observed to erythromycin in all regions. Susceptibility to ciprofloxacin showed large variation (25%, 75% and 84% in the Americas, Europe and Australia-Asia, respectively). Two vancomycin-intermediate PVL-positive MRSA isolates were reported, one from Hong Kong and the other from The Netherlands. Resistance to trimethoprim/sulfamethoxazole and linezolid was <1%. Among 1798 MRSA isolates from 13 countries that were tested for the requested 10 non-β-lactam antibiotics, 49.4% were multisusceptible. However, multiresistant isolates (resistant to at least three classes of non-β-lactam antibiotics) were reported from all regions. Sequence type 30 (ST30) was reported worldwide, whereas ST80 and ST93 were exclusive to Europe and Australia, respectively. USA300 and related clones (ST8) are progressively replacing the ST80 clone in several European countries. Eight major clusters were discriminated by multilocus variable-number tandem repeat assay (MLVA), showing a certain geographic specificity. PVL-positive MRSA isolates frequently remain multisusceptible to non-β-lactam agents, but multiresistance is already prevalent in all regions. Surveillance of MRSA susceptibility patterns should be monitored to provide clinicians with the most current information regarding changes in resistance patterns.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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