Affiliations 

  • 1 a Institute of Biological Sciences, Faculty of Science, University of Malaya , Kuala Lumpur , Malaysia
  • 2 b Biology Division , Centre for Foundation Studies in Science, University of Malaya , Kuala Lumpur , Malaysia
Nucleosides Nucleotides Nucleic Acids, 2017 Apr 03;36(4):243-255.
PMID: 28323520 DOI: 10.1080/15257770.2016.1268693

Abstract

This study aims to investigate the mechanisms associated with the antiproliferation effect of guanosine on human colon carcinoma HCT 116 cells. In this study, guanosine induced more drastic cell cycle arrest effect than cell death effect on HCT 116 cells. The cell cycle arrest effect of guanosine on HCT 116 cells appeared to be associated with the increased activation of mitogen-activated protein kinases (MAPK) such as ERK1/2, p38 and JNK. The decrease of AMP-activated protein kinase (AMPK) activation and cyclin D1 expression was also involved. Thus, the antiproliferation of colon cancer cells of guanosine could be mediated by the disruption of MAPK and AMPK pathways.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.