Affiliations 

  • 1 Hoshi University Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan
  • 2 Department of Chemistry, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia
  • 3 Hoshi University Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo 142-8501, Japan. Electronic address: moritah@hoshi.ac.jp
Bioorg Med Chem Lett, 2017 May 15;27(10):2124-2128.
PMID: 28389148 DOI: 10.1016/j.bmcl.2017.03.071

Abstract

Vasorelaxation activity guided separation of the methanol extract of Calophyllum scriblitifolium bark led to the isolation of 6 chromanones (calofolic acids A-F, 1-6). Their structures were elucidated by 1D and 2D NMR spectroscopy, and their absolute configurations were investigated by a combination of CD spectroscopy and DFT calculation. All isolated chromanones showed dose-dependent vasorelaxation activity on isolated rat aorta.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.