Bisnicalaterine A, a vobasine-vobasine bisindole alkaloid from Hunteria zeylanica

Nugroho AE 1 , Hirasawa Y , Kawahara N , Goda Y , Awang K , Hadi AH Show all authors , Morita H

Affiliations 

  • 1 Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan
J Nat Prod, 2009 Aug;72(8):1502-6.
PMID: 19388660 DOI: 10.1021/np900115q

Abstract

A new bisindole alkaloid, bisnicalaterine A (1), consisting of two vobasine-type skeletons, and 3-epivobasinol (2) and 3-O-methylepivobasinol (3), with vobasine-type skeletons, were isolated from the leaves of Hunteria zeylanica, and their structures were elucidated on the basis of spectroscopic data and chemical correlation. Bisnicalaterine A showed moderate cytotoxicity against various human cancer cell lines.

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