Neolamarckines A and B, new indole alkaloids from Neolamarckia cadamba

Qureshi AK 1 , Mukhtar MR , Hirasawa Y , Hosoya T , Nugroho AE , Morita H Show all authors , Shirota O , Mohamad K , Hadi AH , Litaudon M , Awang K

Affiliations 

  • 1 Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
Chem Pharm Bull (Tokyo), 2011;59(2):291-3.
PMID: 21297315

Abstract

Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.

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