• 1 Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
  • 2 Division of Neurology, University Medicine Cluster, National University Hospital, NUHS Tower Block, Level 10, 119228, Singapore
  • 3 Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 4 National Neuroscience Institute, Singapore
Muscle Nerve, 2017 Nov;56(5):919-924.
PMID: 28093784 DOI: 10.1002/mus.25577


INTRODUCTION: In this study we propose electrodiagnostic criteria for early reversible conduction failure (ERCF) in axonal Guillain-Barré syndrome (GBS) and apply them to a cohort of GBS patients.

METHODS: Serial nerve conduction studies (NCS) were retrospectively analyzed in 82 GBS patients from 3 centers. The criteria for the presence of ERCF in a nerve were: (i) a 50% increase in amplitude of distal compound muscle action potentials or sensory nerve action potentials; or (ii) resolution of proximal motor conduction block with an accompanying decrease in distal latencies or compound muscle action potential duration or increase in conduction velocities.

RESULTS: Of 82 patients from 3 centers, 37 (45%) had ERCF, 21 (26%) had a contrasting evolution pattern, and 8 (10%) had both. Sixteen patients did not show an amplitude increase of at least 50%.

CONCLUSION: Our proposed criteria identified a group of patients with a characteristic evolution of NCS abnormality that is consistent with ERCF. Muscle Nerve 56: 919-924, 2017.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.