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Genome Sequence of a Novel HIV-1 Circulating Recombinant Form (CRF77_cpx) Identified among Blood Donors in Malaysia

Tee KK 1 , Bon AH 2 , Chow WZ 3 , Ng KT 3 , Chan KG 4 , Kamarulzaman A 3 Show all authors , Busch MP 5 , Takebe Y 6

Affiliations 

  • 1 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia k2tee@um.edu.my
  • 2 National Blood Centre of Kuala Lumpur (NBCKL), Kuala Lumpur, Malaysia
  • 3 Centre of Excellence for Research in AIDS (CERiA), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 4 Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
  • 5 Blood Systems Research Institute (BSRI), San Francisco, California, USA
  • 6 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Genome Announc, 2017 Jun 29;5(26).
PMID: 28663289 DOI: 10.1128/genomeA.00459-17

Abstract

We report here the first HIV-1 circulating recombinant form (CRF) complex identified among the blood donors in Malaysia. The CRF77_cpx mosaic genome consists of parental subtypes B', C, and CRF01_AE and is structurally related to CRF07_BC. The identification of CRF77_cpx underlines the genetic complexity and mobility of HIV-1 among the blood donors.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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