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Genome Sequence of Complex HIV-1 Unique Recombinant Forms Sharing a Common Recombination Breakpoint Identified in Malaysia

Cheong HT 1 , Ng KT 1 , Ong LY 1 , Takebe Y 2 , Chan KG 3 , Koh C 1 Show all authors , Al-Darraji HA 1 , Kamarulzaman A 1 , Tee KK 4

Affiliations 

  • 1 Centre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Centre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan School of Medicine, Yokohama City University, Yokohama, Kanagawa, Japan
  • 3 Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
  • 4 Centre of Excellence for Research in AIDS (CERiA), Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia k2tee@um.edu.my
Genome Announc, 2015;3(6).
PMID: 26543107 DOI: 10.1128/genomeA.01220-15

Abstract

Three strains of HIV-1 unique recombinant forms (URFs) descended from subtypes B, B', and CRF01_AE were identified among people who inject drugs in Kuala Lumpur, Malaysia. These three URFs shared a common recombination breakpoint in the reverse transcriptase region, indicating frequent linkage within the drug-injecting networks in Malaysia.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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