Affiliations 

  • 1 Department of Ophthalmology, IMU clinical school, International Medical University, Seremban, Negeri Sembilan, Malaysia
  • 2 Department of Community Medicine, Faculty of Medicine & Defence Health, National Defence University of Malaysia, Sungai Besi Camp, 57000 KL, Malaysia
  • 3 Department of Pharmacology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh campus, Jalan Hospital, 47000, Sungai Buloh, Selangor Darul Ehsan, Malaysia
Mol Vis, 2015;21:612-20.
PMID: 26019480

Abstract

Elevated intraocular pressure (IOP) in glaucomatous eyes is often due to increased resistance to aqueous outflow. Previous studies have shown that increased extracellular material deposition in outflow pathways leads to increased resistance to aqueous outflow, and transforming growth factor (TGF)-β seems to play a role in the deposition of extracellular material. TGF-β2 is the predominant isoform in ocular tissue. Hence, comparison of the aqueous humor TGF-β2 level between patients with open-angle glaucoma (OAG) and controls would provide direct evidence for the role of TGF-β2 in the etiology of OAG. Hence, we performed this meta-analysis to develop an accurate estimate of the changes in aqueous humor TGF-β2 levels among OAG patients.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.