Unmistakable Morphology? Infantile Malignant Osteopetrosis Resembling Juvenile Myelomonocytic Leukemia in Infants

Strauss A 1 , Furlan I 2 , Steinmann S 2 , Buchholz B 3 , Kremens B 4 , Rossig C 5 Show all authors , Corbacioglu S 6 , Rajagopal R 7 , Lahr G 2 , Yoshimi A 8 , Strahm B 8 , Niemeyer CM 8 , Schulz A 2

Affiliations 

  • 1 Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany. Electronic address: anne.strauss@uniklinik-freiburg.de
  • 2 Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany
  • 3 Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  • 4 Department of Pediatric Hematology and Oncology, University of Duisburg-Essen, Essen, Germany
  • 5 Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster, Muenster, Germany
  • 6 Department of Pediatric Hematology, Oncology and Stem Cell Transplantation, University of Regensburg, Children's Hospital Regensburg, Regensburg, Germany
  • 7 Pediatric Hematology-Oncology Unit, University of Malaya Medical Center, Kuala Lumpur, Malaysia
  • 8 Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
J Pediatr, 2015 Aug;167(2):486-8.
PMID: 25982139 DOI: 10.1016/j.jpeds.2015.04.064

Abstract

The initial clinical and hematologic presentation of infantile malignant osteopetrosis may be indistinguishable from that of juvenile myelomonocytic leukemia in infants. Timely radiographic imaging, however, allows straightforward delineation of these 2 severe diseases and facilitates immediate initiation of appropriate therapy.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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