Affiliations 

  • 1 Inamori School of Engineering, Alfred University, Alfred, New York, 14802, USA. wren@alfred.edu
  • 2 Inamori School of Engineering, Alfred University, Alfred, New York, 14802, USA
  • 3 School of Materials Engineering, Purdue University, West Lafayette, Indiana, USA
  • 4 Department of Mechanical & Industrial Engineering, Ryerson University, Toronto, Canada
Macromol Biosci, 2015 Aug;15(8):1146-58.
PMID: 25923463 DOI: 10.1002/mabi.201500109

Abstract

Silver (Ag) coated bioactive glass particles (Ag-BG) were formulated and compared to uncoated controls (BG) in relation to glass characterization, solubility and microbiology. X-ray diffraction (XRD) confirmed a crystalline AgNP surface coating while ion release studies determined low Ag release (<2 mg/L). Cell culture studies presented increased cell viability (127 and 102%) with lower liquid extract (50 and 100 ml/ml) concentrations. Antibacterial testing of Ag-BG in E. coli, S. epidermidis and S. aureus significantly reduced bacterial cell viability by 60-90%. Composites of Ag-BG/CMC-Dex Hydrogels were formulated and characterized. Agar diffusion testing was conducted where Ag-BG/hydrogel composites produced the largest inhibition zones of 7 mm (E. coli), 5 mm (S. aureus) and 4 mm (S. epidermidis).

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.