Neuronal transcriptomic responses to Japanese encephalitis virus infection with a special focus on chemokine CXCL11 and pattern recognition receptors RIG-1 and MDA5

Yu SP 1 , Ong KC 2 , Perera D 3 , Wong KT 4

Affiliations 

  • 1 Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Institute of Health and Community Medicine, University Malaysia Sarawak, Sarawak, Malaysia
  • 4 Department of Pathology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address: wongkt@ummc.edu.my
Virology, 2019 01 15;527:107-115.
PMID: 30481615 DOI: 10.1016/j.virol.2018.10.015

Abstract

Japanese encephalitis virus (JEV) causes central nervous system neuronal injury and inflammation. A clear understanding of neuronal responses to JEV infection remains elusive. Using the Affymetrix array to investigate the transcriptome of infected SK-N-MC cells, 1316 and 2737 dysregulated genes (≥ 2/-2 fold change, P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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