• 1 a Malaysian Institute of Pharmaceuticals and Nutraceuticals, NIBM , Ministry of Science Technology and Innovation (MOSTI) , Pulau Pinang , Malaysia
  • 2 b Institute for Research in Molecular Medicine (INFORMM) , Universiti Sains Malaysia , Pulau Pinang , Malaysia
J Asian Nat Prod Res, 2019 Aug;21(8):754-771.
PMID: 30606060 DOI: 10.1080/10286020.2018.1520704


Andrographolide, a major bioactive compound isolated from Andrographis paniculata (Burm. F.) Nees, was evaluated for its effects on the hOAT1 membrane transporter. Substrate determination and inhibition of hOAT1-mediated uptake transport assay was carried out using recombinant CHO-hOAT1 cells. The results showed that the uptake ratio of andrographolide was less than 2.0 at all concentrations tested, indicating that andrographolide is not a hOAT1 substrate. Andrographolide has no significant effects on the p-aminohippuric acid uptake and on the mRNA and protein expression of hOAT1. In conclusion, andrographolide may not pose a drug-herb interaction risk related to hOAT1.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.