Helicobacter pylori overcomes natural immunity in repeated infections

Stenström B 1 , Windsor HM 2 , Fulurija A 3 , Benghezal M 4 , Kumarasinghe MP 5 , Kimura K 6 Show all authors , Tay CY 2 , Viiala CH 1 , Ee HC 1 , Lu W 3 , Schoep TD 7 , Webberley KM 2 , Marshall BJ 8

Affiliations 

  • 1 Department of Gastroenterology Sir Charles Gairdner Hospital Perth Western Australia Australia
  • 2 The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia
  • 3 The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia; Ondek Pty Ltd QEII Medical Centre Perth Western Australia Australia
  • 4 The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia; Ondek Pty Ltd QEII Medical Centre Perth Western Australia Australia; Swiss Vitamin Institute Épalinges Switzerland
  • 5 Department of Anatomical Pathology PathWest, QEII Medical Centre Perth Western Australia Australia
  • 6 Department of Gastroenterology Sir Charles Gairdner Hospital Perth Western Australia Australia; The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia; Venasis Kanamachi Medical Clinic Tokyo-to Japan
  • 7 Ondek Pty Ltd QEII Medical Centre Perth Western Australia Australia; Telethon Kids Institute Perth Western Australia Australia
  • 8 The Marshall Centre for Infectious Diseases Research and Training School of Pathology and Laboratory Medicine The University of Western Australia Perth Western Australia Australia; UM Marshall Centre University of Malaya Kuala Lumpur Malaysia
Clin Case Rep, 2016 11;4(11):1026-1033.
PMID: 27830066

Abstract

Repeated experimental reinfection of two subjects indicates that Helicobacter pylori infection does not promote an immune response protective against future reinfection. Our results highlight the importance of preventing reinfection after eradication, through public health initiatives, and possibly treatment of family members. They indicate difficulties for vaccine development, especially therapeutic vaccines.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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