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Comparing the genomes of Helicobacter pylori clinical strain UM032 and Mice-adapted derivatives

Khosravi Y 1 , Rehvathy V 1 , Wee WY 2 , Wang S 3 , Baybayan P 3 , Singh S 4 Show all authors , Ashby M 3 , Ong J 5 , Amoyo AA 5 , Seow SW 5 , Choo SW 2 , Perkins T 6 , Chua EG 7 , Tay A 7 , Marshall BJ 7 , Loke MF 1 , Goh KL 8 , Pettersson S 9 , Vadivelu J 1

Affiliations 

  • 1 Department of Medical Microbiology, University of Malaya, Kuala Lumpur, Malaysia
  • 2 Dental Research and Training Unit, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia
  • 3 Pacific Biosciences, Menlo Park, California, USA
  • 4 PacBio Singapore, Singapore, Singapore
  • 5 National Cancer Centre, Singapore, Singapore
  • 6 School of Pathology and Laboratory Medicine, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Perth, Western Australia, Australia
  • 7 The Marshall Centre for Infectious Diseases Research and Training, University of Western Australia, Perth, Western Australia, Australia
  • 8 Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia
  • 9 National Cancer Centre, Singapore, Singapore ; Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden ; School of Biological Sciences, Nanyang Technological University, Singapore, Singapore
Gut Pathog, 2013;5:25.
PMID: 23957912 DOI: 10.1186/1757-4749-5-25

Abstract

Helicobacter pylori is a Gram-negative bacterium that persistently infects the human stomach inducing chronic inflammation. The exact mechanisms of pathogenesis are still not completely understood. Although not a natural host for H. pylori, mouse infection models play an important role in establishing the immunology and pathogenicity of H. pylori. In this study, for the first time, the genome sequences of clinical H. pylori strain UM032 and mice-adapted derivatives, 298 and 299, were sequenced using the PacBio Single Molecule, Real-Time (SMRT) technology.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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