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Synthesis, structural and antioxidant studies of some novel N-ethyl phthalimide esters

Chidan Kumar CS 1 , Loh WS 2 , Chandraju S 3 , Win YF 4 , Tan WK 5 , Quah CK 2 Show all authors , Fun HK 6

Affiliations 

  • 1 X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang, Malaysia; Department of Chemistry, Alva's Institute of Engineering & Technology, Mijar, Karnataka, India
  • 2 X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang, Malaysia
  • 3 Department of Sugar Technology & Chemistry, University of Mysore, Sir M.V. PG Center, Tubinakere, Karnataka, India
  • 4 Department of Chemical Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak Campus, Jalan Universiti, Bandar Barat, Perak, Malaysia
  • 5 Klinik Kesihatan Batu Kawa, Jalan Stapok Utara/ Utara, Kuching, Sarawak, Malaysia
  • 6 X-ray Crystallography Unit, School of Physics, Universiti Sains Malaysia, Penang, Malaysia; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
PLoS One, 2015;10(3):e0119440.
PMID: 25742494 DOI: 10.1371/journal.pone.0119440

Abstract

A series of N-ethyl phthalimide esters 4(a-n) were synthesized and characterized by spectroscopic studies. Further, the molecular structure of majority of compounds were analysed by single crystal X-ray diffraction studies. The X-ray analysis revealed the importance of substituents on the crystal stability and molecular packing. All the synthesized compounds were tested for in vitro antioxidant activity by DPPH radical scavenging, FRAP and CUPRAC methods. Few of them have shown good antioxidant activity.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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