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Boron Nitride Doped Polyhydroxyalkanoate/Chitosan Nanocomposite for Antibacterial and Biological Applications

Mukheem A 1 , Shahabuddin S 2 , Akbar N 3 , Miskon A 4 , Muhamad Sarih N 5 , Sudesh K 6 Show all authors , Ahmed Khan N 7 , Saidur R 8 , Sridewi N 9

Affiliations 

  • 1 Department of Maritime Science and Technology, Faculty of Defence Science and Technology, National Defence University of Malaysia, Kuala Lumpur 57000, Malaysia. mukheembio@gmail.com
  • 2 Research Centre for Nano-Materials and Energy Technology (RCNMET), School of Science and Technology, Sunway University, Subang Jaya 47500, Malaysia. syedshahab.hyd@gmail.com
  • 3 Department of Biological Sciences, School of Science and Technology, Sunway University, Subang Jaya 47500, Malaysia. noormicrobiologist555@gmail.com
  • 4 Department of Maritime Science and Technology, Faculty of Defence Science and Technology, National Defence University of Malaysia, Kuala Lumpur 57000, Malaysia. azizimis@gmail.com
  • 5 Polymer Research Laboratory, Department of Chemistry, University of Malaya, Faculty of Science, Kuala Lumpur 50603, Malaysia. nmsarih@um.edu.my
  • 6 Applied Microbiology and Ecobiomaterial Research Laboratory, School of Biological Sciences, Universiti Sains Malaysia, Penang 11800, Malaysia. ksudesh@usm.my
  • 7 Department of Biological Sciences, School of Science and Technology, Sunway University, Subang Jaya 47500, Malaysia. naveedk@sunway.edu.my
  • 8 Research Centre for Nano-Materials and Energy Technology (RCNMET), School of Science and Technology, Sunway University, Subang Jaya 47500, Malaysia. saidur@sunway.edu.my
  • 9 Department of Maritime Science and Technology, Faculty of Defence Science and Technology, National Defence University of Malaysia, Kuala Lumpur 57000, Malaysia. nanthini@upnm.edu.my
Nanomaterials (Basel), 2019 Apr 21;9(4).
PMID: 31010071 DOI: 10.3390/nano9040645

Abstract

The present research focused on the fabrication of biocompatible polyhydroxyalkanoate, chitosan, and hexagonal boron nitride incorporated (PHA/Ch-hBN) nanocomposites through a simple solvent casting technique. The fabricated nanocomposites were comprehensively characterized by Fourier transform infrared spectroscope (FT-IR), field emission scanning electroscope (FESEM), and elemental mapping and thermogravimetric analysis (TGA). The antibacterial activity of nanocomposites were investigated through time-kill method against multi drug resistant (MDR) microbes such as methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) K1 strains. In addition, nanocomposites have examined for their host cytotoxicity abilities using a Lactate dehydrogenase (LDH) assay against spontaneously immortalized human keratinocytes (HaCaT) cell lines. The results demonstrated highly significant antibacterial activity against MDR organisms and also significant cell viability as compared to the positive control. The fabricated PHA/Ch-hBN nanocomposite demonstrated effective antimicrobial and biocompatibility properties that would feasibly suit antibacterial and biomedical applications.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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