This initial study was conducted from September to February 2009 to examine predictors of general well-being among academic college residents at a higher learning institution. A set of questions was sent to 150 students who identified themselves as residents of the academic college, Universiti Kebangsaan Malaysia. The Eysenck Personality Questionnaire - short version was used to measure personality traits.The Rosenberg Self-esteem Questionnairewas used to measure self-esteem and Satisfaction with Life Scale to measure life-satisfaction. The general well-being scale was used to measure general well-being. Inter-correlation analysis has shown that extraversion was significantly correlated to self-esteem, life-satisfaction and general well-being whilst life-satisfaction was significantly correlated to general well-being. Multiple regression analysis showed that three factors significantly contributed to general well-being with a 24% explained variance. No significant differences were found between gender and general well-being.