• 1 MD (USM), FRCP (EDINBURGH) Department of Cardiology, Sultanah Aminah Hospital, 8 Jalan Masjid Abu Bakar, 80100 Johor Bahru Johor, Malaysia.
  • 2 MD (UKM), FRACGP (Australia] MRCP (London) Ledang Specialist Clinic, 141 Jalan Muar, 84900 Tangkak Johor, Malaysia
  • 3 MBBS (Singapore), MASTER OF MEDICINCE IM (Singapore], FAFPM (Malaysia), Klinik Malaysia, 118, Jalan, Mersing, 86000 Kluang, Johor Malaysia
  • 4 MBBS (UM), AM (MAL), FRCP, (Glasgow), Klinik Pakar Perubatan Century 14A, Jalan Harimau, Century Garden 80250 Johor Bahru, Johor Malaysia
  • 5 MD (Monash, Australia), MPH, PhD (Japan), Clinical School Johor Bahru Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, 8 Jalan Masjid Abu Bakar, 80100 Johor Bahru Johor, Malaysia
Malays Fam Physician, 2019;14(2):39-43.
PMID: 31827736


Diuretics have a long and distinguished history in the treatment of hypertension and heart failure. Clinical practice guidelines recommend that diuretics should be considered to be as suitable as other antihypertensive agents for the initiation and maintenance of antihypertensive treatment. However, diuretics may potentially cause electrolyte disturbances and metabolic side effects. Diuretic-induced hyponatremia is probably more prevalent than generally acknowledged. We present an unusual case of indapamide-induced hyponatremia and hypokalemia complicated by cardiac arrhythmia. The adverse drug reaction was reversible and non-life-threatening, but this case serves as a reminder that careful evaluation and constant monitoring are necessary when prescribing diuretics.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.