Displaying publications 1 - 20 of 104 in total

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  1. Falkner PH
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
  2. Goldstein G
    Med. J. Aust., 1980 Jan 12;1(1):39.
    PMID: 7360078
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions*
  3. LIM G
    Med J Malaya, 1961 Mar;15:157-9.
    PMID: 14465286
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions*
  4. Reddy SVG
    Family Physician, 1989;1:42-42.
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions*
  5. Jaiprakash H, Narayana S, Mohanraj J
    N Am J Med Sci, 2012 Feb;4(2):90-3.
    PMID: 22408755 DOI: 10.4103/1947-2714.93385
    Liver is the main organ for metabolism of drugs and hepatotoxicity is a potential adverse effect for most drugs.
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
  6. Agarwal R, Daher AM, Mohd Ismail N
    Malays J Med Sci, 2013 Mar;20(2):52-61.
    PMID: 23983578 MyJurnal
    The study aimed to determine current status of knowledge, practices, and attitudes towards adverse drug reaction (ADR) reporting among private practitioners in Klang region of Malaysia.
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
  7. Khan Q, Akmeliawati R, Bhatti AI, Khan MA
    ISA Trans, 2017 Jan;66:241-248.
    PMID: 27884392 DOI: 10.1016/j.isatra.2016.10.017
    This paper presents a fast terminal sliding mode based control design strategy for a class of uncertain underactuated nonlinear systems. Strategically, this development encompasses those electro-mechanical underactuated systems which can be transformed into the so-called regular form. The novelty of the proposed technique lies in the hierarchical development of a fast terminal sliding attractor design for the considered class. Having established sliding mode along the designed manifold, the close loop dynamics become finite time stable which, consequently, result in high precision. In addition, the adverse effects of the chattering phenomenon are reduced via strong reachability condition and the robustness of the system against uncertainties is confirmed theoretically. A simulation as well as experimental study of an inverted pendulum is presented to demonstrate the applicability of the proposed technique.
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
  8. Green R
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
  9. Menon PK
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
  10. Landor JV
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
  11. Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
  12. Abubakar AR, Chedi BA, Mohammed KG, Haque M
    J Adv Pharm Technol Res, 2015 Oct-Dec;6(4):154-8.
    PMID: 26605155 DOI: 10.4103/2231-4040.165021
    Spontaneous reporting (SPR) and intensive monitoring are the conventional systems used for detecting, recording, and reporting adverse drug reactions (ADRs). Using spontaneous reporting a lot of successes has been made as existing ADRs were identified and new ones prevented through this methods. The aim of this appraisal was to evaluate the knowledge, attitude, and the practice of medical students with regards to ADRs reporting and to see if differences exist between the level of study and genders. The questionnaire was adopted, modified, and validated from previous studies. It comprised of 25 questions. It was administered year-IV and V medical students of Bayero University Kano, Nigeria. The data collected were coded and analyzed using the Statistical Package for the Social Sciences (SPSS) version 20, currently known as IBM SPSS Statistics. The response rate was 74%. Among the 108 participants, 80% got the definition of ADRs correct; 63% of them knew the precise functions of pharmacovigilance (PV). In addition, 82% strongly agreed that ADR reporting is health care workers responsibility; 82% also said PV should be taught in detail. Meanwhile, 99% have noticed patient experiencing ADRs; 67% said even mild ADRs should be reported. The outcome of this study showed good knowledge and attitude with respect to ADRs and PV among the medical students surveyed. Unfortunately, the practice of medical students was found to be unsatisfactory. There is a need to upgrade the students teaching the curriculum with respect to ADRs monitoring.
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions*
  13. Jatau AI, Aung MM, Kamauzaman TH, Rahman AF
    Drugs Real World Outcomes, 2015 10 23;2(4):387-395.
    PMID: 26689834
    BACKGROUND: Data on the prevalence of adverse drug event (ADE)-related emergency department (ED) visits in developing countries are limited. Malaysia is located in South-East Asia, and, to our knowledge, no information exists on ADE-related ED visits.

    OBJECTIVE: The objective of this study was to determine the prevalence, preventability, severity, and outcome of drug-related ED visits.

    METHODOLOGY: A cross-sectional study was conducted in consenting patients who visited the ED of Hospital Universiti Sains Malaysia over a 6-week period. The ED physician on duty determined whether or not the visit was drug related according to set criteria. Other relevant information was extracted from the patient's medical folder by a clinical pharmacist.

    RESULTS: Of the 434 consenting patients, 133 (30.6 %; 95 % confidence interval [CI] 26-35 %) visits were determined to be ADE related; 55.5 % were considered preventable, 11.3 % possibly preventable, and 33.1 % not preventable. Severity was classed as mild in 1.5 %, moderate in 67.7 %, and severe in 30.8 %. The most common ADEs reported were drug therapeutic failure (55.6 %) and adverse drug reactions (32.3 %). The most frequently implicated drugs were antidiabetics (n = 31; 23.3 %), antihypertensives (n = 28; 21.1 %), antibiotics (n = 13; 9.8 %), and anti-asthmatics (n = 11; 8.3 %). A total of 93 patients (69.9 %) were admitted to the ED for observation, 25 (18.8 %) were discharged immediately after consultation, and 15 (11.3 %) were admitted to the ward through the ED.

    CONCLUSION: The prevalence of ADE-related ED visits was high; more than one-half of the events were considered preventable and one-third was classed as severe. As such, preventive measures will minimize future occurrences and increase patient safety.
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions*
  14. Umair Khan M, Ahmad A, Ejaz A, Ata Rizvi S, Sardar A, Hussain K, et al.
    PMID: 26072906 DOI: 10.3352/jeehp.2015.12.28
    PURPOSE: The goal of this study was to compare the knowledge and attitudes of pharmacy and medical students regarding adverse drug reactions (ADRs), as well as their perceptions of barriers to ADR reporting, in a Higher Education Commission-recognised Pakistani university.
    METHODS: A cross-sectional study was conducted among final-year pharmacy (n=91) and medical (n=108) students in Pakistan from June 1 to July 31, 2014. A self-administered questionnaire was used to collect the data. The responses of pharmacy students were compared to those of medical students.
    RESULTS: Pharmacy students had a significantly better knowledge of ADRs than medical students (mean±SD, 5.61±1.78 vs. 3.23±1.60; P<0.001). Gender showed a significant relationship to knowledge about ADRs, and male participants were apparently more knowledgeable than their female counterparts (P<0.001). The attitudes of pharmacy students regarding their capability to handle and report ADRs were significantly more positive than those of medical students (P<0.05). In comparison to pharmacy students, a lack of knowledge of where and how to report ADRs was the main barrier that medical students perceived to ADR reporting (P=0.001).
    CONCLUSION: Final-year pharmacy students exhibited more knowledge about ADRs and showed more positive attitudes regarding their capacity to handle and report ADRs than final-year medical students.
    KEYWORDS: Comparison; Medical; Pakistan; Pharmacovigilance; Pharmacy; Students
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions*
  15. Nik Muhamad, N.A., Ismail, A.K., Kaharuddin, H., Miao Ching, H., Qamarul Ariffin, S., Syazwani Azwa, S., et al.
    Medicine & Health, 2016;11(1):2-10.
    MyJurnal
    Midazolam is one of the most commonly used drugs for sedation in Emergency Department (ED). This was a retrospective study conducted on 380 patients from December 2012 to May 2014 in ED of Universiti Kebangsaan Malaysia Medical Centre (UKMMC). The objective was to elicit the frequency of side effects and correlation to various factors i.e. socio-demography, co-morbidities, age groups and underlying illnesses. Out of 380 patients, 35 patients experienced side effects (20 patients with midazolam alone, 15 patients with combination of drugs). The average age was 42 years and the average dose of midazolam was 3.5mg. The most common other drug combined was fentanyl. The overall complication rate for midazolam was 5.3%. The most common side effect recorded was excessive somnolence (1.6%). Other side effects included local skin reactions (1.1%), vomiting (0.8%), headache (0.8%) and hypotension (0.5%). There was no significant association between the socio-demographic factors and drugs combination with the side effects of midazolam on patients. It was concluded that midazolam was a safe drug due to absence of any life-threatening side effects. There are possibilities that most side effects recorded could be caused by other comfounding factors e.g. underlying injuries or disease and combination with other drugs.
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions*
  16. Chia, L.C., Ahmad Nabil, M.R., Marhani, M., Muna Hamiza, A.
    Medicine & Health, 2017;12(1):122-126.
    MyJurnal
    This report stresses on the occurrence of a rare adverse reaction to clozapine, i.e. allergic cutaneous and visceral angioedema, in a patient with treatment resistant schizophrenia (TRS). We report the case of a schizophrenic patient who was resistant to treatment and developed an allergic reaction involving her skin and gastro-intestinal system upon the commencement of clozapine. She was then treated with a combination pharmacotherapy which left some residual symptoms. The manifestation of allergic reactions to clozapine and its management strategies are discussed in the paper. There is a pressing need to develop a new psychotropic which is on par with clozapine.
    Keywords: allergy, angioedema, clozapine, schizophrenia
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions*
  17. Leelavathi M, Tzar MN
    Malays Fam Physician, 2011;6(2-3):58-9.
    PMID: 25606224
    The clinical suspicion of onychomyosis based on appearance of the nails, requires culture for confirmation. This is because treatment requires prolonged use of systemic agents which may cause side effects. One of the common problems encountered is improper nail sampling technique which results in loss of essential information. The unfamiliar terminologies used in reporting culture results may intimidate physicians resulting in misinterpretation and hamper treatment decision. This article provides a simple guide on nail sampling technique and the interpretation of culture results.
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
  18. Zahari Z, Salleh MR, Teh LK, Ismail R
    Malays J Med Sci, 2009 Jul;16(3):12-20.
    PMID: 22589660 MyJurnal
    Our objective was to investigate the association of CYP2D6 polymorphisms with symptoms and side-effects of patients with schizophrenia.
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
  19. Das Gupta E
    Malays Fam Physician, 2009;4(2-3):48-50.
    PMID: 25606162 MyJurnal
    No screening test is ideal for detecting rheumatic diseases; diagnosis depends on appropriate history and thorough physical examination. Sometimes, laboratory investigations may be useful in confirming or ruling out rheumatic disease after a clinical diagnosis is considered. Once a rheumatic disease has been diagnosed, certain laboratory tests can help in assessing prognosis or determining the extent of the disease. Laboratory tests may also help the physician monitor certain rheumatic diseases, guide treatment or assess potential drug toxicity.
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
  20. Stephen Ambu
    MyJurnal
    The global environment is in a dynamic flux due to rapid development. As a result of this, new
    diseases are emerging and old diseases are re-emerging in many parts of the world. Therefore there is a constant need for appropriate data for formulation of effective policies to mitigate the adverse effects of environmental degradation on human health. The Kyoto Protocol of 1997 is a milestone that sets the direction for good environmental management initiatives and the success
    of this depends on good data. Malaysia currently has the Environmental Quality Act 1974 in place to
    control environment related problems. However good guidelines must be developed to keep the initiatives for good environmental management on course, for this we need good data. The Centre for Environmental and Population Health at IMU, coordinates research activities in specific thrust areas in an endeavour to produce important data that is required for developing appropriate guidelines for environmental health.
    Matched MeSH terms: Drug-Related Side Effects and Adverse Reactions
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