Management of bleeding irregularities among etonogestrel implant users: Is combined oral contraceptives pills or nonsteroidal anti-inflammatory drugs the better option?

Upawi SN 1 , Ahmad MF 2 , Abu MA 2 , Ahmad S 2

Affiliations 

  • 1 Obstetrics & Gynaecology Department, Shah Alam Hospital, Shah Alam, Malaysia
  • 2 Obstetrics & Gynaecology Department, UKM Medical Center, Kuala Lumpur, Malaysia
J Obstet Gynaecol Res, 2020 Mar;46(3):479-484.
PMID: 31958877 DOI: 10.1111/jog.14195

Abstract

AIM: This study is to evaluate whether unacceptable bleeding among the etonogestrel implant user could be better alleviated using combined oral contraceptive pills (COCP) or nonsteroidal anti-inflammation drugs (NSAID).

METHODS: This is a prospective randomized study for evaluation of 84 etonogestrel implant (Implanon) users with prolonged or frequent bleeding. They were assigned to either receiving a COCP containing 20 mcg ethinyl estradiol/150 mg desogestrel for two continuous cycle or NSAID; mefenamic acid 500 mg TDS for 5 days, 21 days apart for two cycles. Bleeding pattern during the treatment was recorded and analyzed.

RESULTS: A total of 32 women (76.2%) in COCP group and 15 women (35.7%) in NSAID group stop bleeding within 7 days after the initiation of treatment which was statistically significant (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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