Affiliations 

  • 1 Department of Biology, Science Faculty, Selçuk University, Campus, Konya, Turkey. Electronic address: gokhanzengin@selcuk.edu.tr
  • 2 Institute of Research and Development, Duy Tan University, Da Nang 550000, VietNam; Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius
  • 3 Department of Biology, Science Faculty, Selçuk University, Campus, Konya, Turkey
  • 4 Department of Health Sciences, Faculty of Science, University of Mauritius, 230 Réduit, Mauritius
  • 5 Department of Biotechnology, Science Faculty, Selçuk University, Campus, Konya, Turkey
  • 6 Agricultural and Molecular Research and Service Institute, University of Nyíregyháza, Nyíregyháza, Hungary
  • 7 School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia; Institute of Pharmaceutical Sciences (IPS), University of Veterinary & Animal Sciences (UVAS), Lahore, Pakistan
  • 8 School of Pharmacy, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor Darul Ehsan, Malaysia
Food Res Int, 2020 07;133:109129.
PMID: 32466933 DOI: 10.1016/j.foodres.2020.109129

Abstract

The Crocus and Cyclamen genus have been reported to possess diverse biological properties. In the present investigation, two geophytes from these genus, namely Crocus pallasi and Cyclamen cilicium have been studied. The in vitro antioxidant, enzyme inhibitory, and cytotoxic effects of the methanol extracts of Crocus pallasii and Cyclamen cilicium aerial and underground parts were investigated. Antioxidant abilities of the extracts were investigated via different antioxidant assays (metal chelating, radical quenching (ABTS and DPPH), reducing power (CUPRAC and FRAP) and phosphomolybdenum). Cholinesterases, amylase, tyrosinase, and glucosidase were used as target enzymes for detecting enzyme inhibitory abilities of the samples. Regarding the cytotoxic abilities, breast cancer cell lines (MDA-MB 231 and MCF-7) and prostate cancer cell lines (DU-145) were used. The flowers extracts of Crocus pallasii and C. cilicium possessed the highest flavonoid content. The highest phenolic content was recorded from C. cilicium root extract (47.62 mg gallic acid equivalent/g extract). Cyclamen cilicium root extract showed significantly (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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