Affiliations 

  • 1 School of Pharmacy, Monash University Malaysia, Selangor Darul Ehsan, Malaysia
  • 2 Department of Biology, Faculty of Science, Selcuk University, Campus/Konya, Turkey
  • 3 Institute of Pharmaceutical Sciences (IPS), University of Veterinary & Animal Sciences (UVAS), Lahore, Pakistan
  • 4 Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
  • 5 Johor Institute of Professional Studies, Lahore, Pakistan
  • 6 Department of Health Sciences, Faculty of Science, University of Mauritius, Mauritius
  • 7 REEF Environmental Consultancy Services, Puducherry, India
  • 8 Institute Bioproduct Development (IBD), Universiti Teknologi Malaysia (UTM), Skudai, Johor Bahru, Johor, Malaysia
  • 9 Liquid Chromatography Mass Spectrometery (LCMS) Platform, Monash University, Selangor Darul Ehsan, Malaysia
Nat Prod Res, 2021 Feb;35(4):664-668.
PMID: 30919661 DOI: 10.1080/14786419.2019.1587427

Abstract

This study sets out to probe into total bioactive contents, UHPLC-MS secondary metabolites profiling, antioxidant (DPPH, ABTS, FRAP, CUPRAC, phosphomolybdenum and metal chelating) and enzyme inhibitory (acetylcholinesterase- AChE, butyrylcholinesterase- BChE, α-amylase, α glucosidase, and tyrosinase) activities of methanol extract of Aerva javanica, also known as desert cotton or Kapok bush. Aerva javanica contains considerable phenolic (44.79 ± 3.12 mg GAE/g) and flavonoid (28.86 ± 0.12 mg QE/g) contents which tends to correlate with its significant antioxidant potential for ABTS, FRAP and CUPRAC assays with values of 101.41 ± 1.18, 124.10 ± 1.71 and 190.22 ± 5.70 mg TE/g, respectively. The UHPLC-MS analysis identified the presence of 45 phytochemicals belonging to six major groups: phenolic, flavonoids, lignin, terpenes, glycoside and alkaloid. Moreover, the plant extract also showed potent inhibitory action against AChE (3.73 ± 0.22 mg GALAE/g), BChE (3.31 ± 0.19 mg GALAE/g) and tyrosinase (126.05 ± 1.77 mg KAE/g). The observed results suggest A. javanica could be further explored as a natural source of bioactive compounds.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

Similar publications