Affiliations 

  • 1 Department of Pharmacognosy and Phytochemistry, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, New Delhi, India
  • 2 Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, New Delhi, India
  • 3 Pharmaceutical Chemistry Unit, Faculty of Pharmacy, AIMST University, Kedah Darul Aman, Malaysia
Nat Prod Res, 2021 Dec;35(23):5055-5065.
PMID: 32498574 DOI: 10.1080/14786419.2020.1775224

Abstract

The present study was intended to evaluate the in vitro (COX-1/COX-2) and in vivo anti-inflammatory and ulcerogenic activity of newer phytoconstituents isolated from the aerial parts of Swertia alata C.B. Clarke (Gentianaceae). For isolation of newer phytoconstituents, the ethanolic extract of aerial parts of S. alata was subjected to column chromatography using mixture of petroleum ether and chloroform in various concentrations, which yielded two phytoisolates characterised as nonacosyl triacontanoate (SA-3) and 8-O-glucpyranosyl-(2-acetyl)-1,3-dihydroxy-5-methoxy-xanthone (SA-9). Identification of compounds was based on melting point, UV, FTIR, 1H-NMR, 13C-NMR and mass spectrometric data. The isolates were screened for in vitro COX-1/COX-2 inhibitory activity, in vivo anti-inflammatory and ulcerogenic activity. Among the two compounds, SA-3 was found to be more effective than SA-9. The ulcerogenic study revealed significant gastric tolerance of SA-3 and SA-9 in comparison to indomethacin.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.