First detection of Klebsiella quasipneumoniae producing OXA-181 carbapenemase in Malaysia

Lau MY 1 , Ponnampalavanar S 2 , Lee WS 3 , Jabar KA 1 , Chua KH 4 , Idris N 1 Show all authors , Chong CW 5 , Yap PSX 1 , Teh CSJ 6

Affiliations 

  • 1 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 2 Department of Infectious Diseases, University Malaya Medical Centre, 50603, Kuala Lumpur, Malaysia
  • 3 Department of Paediatrics, Faculty of Medicine, University Malaya, 50603, Kuala Lumpur, Malaysia
  • 4 Department of Biomedical Science, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia
  • 5 School of Pharmacy, Monash University Malaysia, 47500, Subang Jaya, Malaysia
  • 6 Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: cindysjteh@um.edu.my
J Infect Chemother, 2020 Oct;26(10):1058-1061.
PMID: 32546330 DOI: 10.1016/j.jiac.2020.05.009

Abstract

The emergence of carbapenemase-producing Enterobacteriaceae has become a major global concern. OXA-48-like carbapenemase gene and its variants have been increasingly reported worldwide. This study reported the first OXA-181-producing Klebsiella quasipneumoniae isolate in Malaysia. This bacterium was isolated from blood specimen of a three-year-old boy with Alagille syndrome who had liver biopsy on October 2016. He had undergone liver transplant in India ten months previously. The genotypic and phenotypic characteristics of the strain were elucidated in this study. To our best knowledge, this is the first report of OXA-181-producing K. quasipneumoniae in Malaysia.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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