Affiliations 

  • 1 Department of Basic Medical Science, Kulliyyah of Nursing, International Islamic University Malaysia, Kuantan, Pahang, Malaysia; Cluster of Oral Cancer Research International Islamic University Malaysia (COCRII), International Islamic University Malaysia, Kuantan, Pahang, Malaysia
  • 2 Department of Paediatric Dentistry and Public Health, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, Malaysia; Cluster of Oral Cancer Research International Islamic University Malaysia (COCRII), International Islamic University Malaysia, Kuantan, Pahang, Malaysia
  • 3 Kulliyyah of Medicine, International Islamic University Malaysia, Pahang, Malaysia; Cluster of Oral Cancer Research International Islamic University Malaysia (COCRII), International Islamic University Malaysia, Kuantan, Pahang, Malaysia
  • 4 Department of Fundamental Dental and Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia, Kuantan, Pahang, Malaysia; Cluster of Oral Cancer Research International Islamic University Malaysia (COCRII), International Islamic University Malaysia, Kuantan, Pahang, Malaysia. Electronic address: hafizarzmi@iium.edu.my
Arch Oral Biol, 2020 Oct;118:104855.
PMID: 32801092 DOI: 10.1016/j.archoralbio.2020.104855

Abstract

OBJECTIVES: This systematic review aimed to investigate the effects if probiotics can inhibit oral carcinogenesis.

DESIGN: PubMed, Web of Science, Scopus, and PLOS databases were searched up to February 2020 to identify randomised controlled trials that fulfilled the eligibility criteria. Joanna Briggs Institute (JBI) Critical Appraisal Tool was used for quality assessment of articles. This review was performed according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA-P) 2015 protocol guidelines.

RESULT: The initial search retrieved 774 articles. Of these, only five articles were included in the qualitative synthesis. Two out of the five papers were further analysed for quantitative synthesis in meta-analysis. The majority of the included studies were found to be of "moderate quality". The qualitative synthesis found four probiotics that exhibited potential therapeutic effects in oral carcinogenesis, includingAcetobacter syzygii, AJ2, Lactobacillus plantarum, and Lactobacillus salivarius REN. Among them, the application of L. salivarius REN resulted in a 95 % lower risk for developing oral cancer (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.