• 1 Department of Biochemistry, Yogi Vemana Universiti, Vemanapuram, Kadapa-516005, A.P, India
  • 2 West High School, Torrance- 90503, CA 90503, United States
  • 3 Institute of Food Security and Sustainable Agriculture (IFSSA) & Faculty of Agrobased Industry (FIAT), Universiti Malaysia Kelantan Campus Jeli, Locked Bag 100, Jeli 17600, Kelantan, Malaysia
Curr Pharm Des, 2021;27(6):802-815.
PMID: 32942973 DOI: 10.2174/1381612826999200917154747


BACKGROUND: Phytoestrogens are non-endocrine, non-steroidal secondary derivatives of plants and consumed through a plant-based diet also named as "dietary estrogens". The major sources of phytoestrogens are soy and soy-based foods, flaxseed, chickpeas, green beans, dairy products, etc. The dietary inclusion of phytoestrogen based foods plays a crucial role in the maintenance of metabolic syndrome cluster, including obesity, diabetes, blood pressure, cancer, inflammation, cardiovascular diseases, postmenopausal ailments and their complications. In recent days, phytoestrogens are the preferred molecules for hormone replacement therapy. On the other hand, they act as endocrine disruptors via estrogen receptor-mediated pathways. These effects are not restricted to adult males or females and identified even in development.

OBJECTIVE: Since phytoestrogenic occurrence is high at daily meals for most people worldwide, they focused to study for its beneficiary effects towards developing pharmaceutical drugs for treating various metabolic disorders by observing endocrine disruption.

CONCLUSION: The present review emphasizes the pros and cons of phytoestrogens on human health, which may help to direct the pharmaceutical industry to produce various phytoestrongen based drugs against various metabolic disorders.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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