Synthesis of enriched boron nitride nanocrystals: A potential element for biomedical applications

Ahmad P 1 , Khandaker MU 2 , Muhammad N 3 , Rehman F 4 , Ullah Z 5 , Khan G 6 Show all authors , Khan MI 4 , Haq S 7 , Ali H 4 , Khan A 8 , Saeed Y 4 , Irshad MI 9

Affiliations 

  • 1 Department of Physics, University of Azad Jammu and Kashmir, 13100, Muzaffarabad, Pakistan; Department of Physics, Faculty of Science University of Malaya, 50603, Kuala Lumpur, Malaysia. Electronic address: pervaiz_pas@yahoo.com
  • 2 Center for Biomedical Physics, Institute for Health Care Development, Sunway University, 47500, Bandar Sunway, Selangor, Malaysia
  • 3 Interdisciplinary Research Centre in Biomedical Materials (IRCBM) COMSATS Institute of Information Technology, 54000, Lahore, Pakistan. Electronic address: nawshadmuhammad@cuilahore.edu.pk
  • 4 Department of Physics, Abbottabad University of Science and Technology, Havelian Khyber Pakhtunkhwa, Pakistan
  • 5 Department of Chemistry, Balochistan University of IT, Engineering and Management Sciences (BUITEMS), Takatu Campus, 87100, Quetta, Pakistan
  • 6 Department of Engineering and Architecture, Balochistan University of IT, Engineering and Management Sciences (BUITEMS), Takatu Campus, 87100, Quetta, Pakistan
  • 7 Department of Chemistry, University of Azad Jammu and Kashmir, 13100, Muzaffarabad, Pakistan
  • 8 Department of Biotechnology, University of Azad Jammu and Kashmir, 13100, Muzaffarabad, Pakistan
  • 9 Department of Physics, Khwaja Fareed University of Engineering and Information Technology, 64200, Rahim Yar Khan, Pakistan
Appl Radiat Isot, 2020 Dec;166:109404.
PMID: 32956924 DOI: 10.1016/j.apradiso.2020.109404

Abstract

The shortcomings in Boron neutron capture therapy (BNCT) and Hyperthermia for killing the tumor cell desired for the synthesis of a new kind of material suitable to be first used in BNCT and later on enable the conditions for Hyperthermia to destroy the tumor cell. The desire led to the synthesis of large band gap semiconductor nano-size Boron-10 enriched crystals of hexagonal boron nitride (10BNNCs). The contents of 10BNNCs are analyzed with the help of x-ray photoelectron spectroscopy (XPS) and counter checked with Raman and XRD. The 10B-contents in 10BNNCs produce 7Li and 4He nuclei. A Part of the 7Li and 4He particles released in the cell is allowed to kill the tumor (via BNCT) whereas the rest produce electron-hole pairs in the semiconductor layer of 10BNNCs suggested to work in Hyperthermia with an externally applied field.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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