A novel rat model of Alzheimer's disease based on lentiviral-mediated expression of mutant APP

Parsi S 1 , Pandamooz S 1 , Heidari S 1 , Naji M 2 , Morfini G 3 , Ahmadiani A 4 Show all authors , Dargahi L 5

Affiliations 

  • 1 Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 2 Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • 3 Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA
  • 4 Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
  • 5 NeuroBiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: l.dargahi@sbmu.ac.ir
Neuroscience, 2015 Jan 22;284:99-106.
PMID: 25270904 DOI: 10.1016/j.neuroscience.2014.09.045

Abstract

Alzheimer's disease (AD) is characterized by progressive and irreversible cognitive and memory impairment. The discovery of familial forms of AD (fAD) in association with specific gene mutations facilitated the generation of numerous rodent models. These models in turn proved valuable for the study of molecular mechanisms underlying AD pathogenesis, and facilitated translational research and preclinical drug development. This study aimed to introduce a new rat model of AD simulating some aspects of the sporadic cases of disease.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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