Non-polyphenolic compounds of a specific kind of dried grape (Maviz) inhibit memory impairments induced by beta-amyloid peptide

Bakhtiyari E 1 , Ahmadian-Attari MM 2 , Salehi P 3 , Khallaghi B 4 , Dargahi L 1 , Mohamed Z 5 Show all authors , Kamalinejad M 6 , Ahmadiani A 4

Affiliations 

  • 1 a NeuroBiology Research Center , Shahid Beheshti University of Medical Sciences , Tehran , Iran
  • 2 b Department of Traditional Medicine , Medicinal Plants Research Center of Barij , Kashan , Iran
  • 3 c Department of Phytochemistry , Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C. , Tehran , Iran
  • 4 d Neuroscience Research Center , Shahid Beheshti University of Medical Sciences , Tehran , Iran
  • 5 e Department of Pharmacology, Faculty of Medicine , University of Malaya , Kuala Lumpur , Malaysia
  • 6 f Department of Pharmacognosy, School of Pharmacy , Shahid Beheshti University of Medical Sciences , Tehran , Iran
Nutr Neurosci, 2017 Oct;20(8):469-477.
PMID: 27219682 DOI: 10.1080/1028415X.2016.1183986

Abstract

OBJECTIVES: Although grape has been recently the topic of many investigations, Maviz (a kind of dried one) has remained neglected. The aim of this study was to assess anti-Alzheimer activity of Maviz.

METHODS: To reach this goal, total phenolic content (TPC) of ethanolic (Eth) and aqueous (Aq) extracts were determined and radical scavenging activity was assayed by 2,2-diphenyl-1-picrylhydrazyl. Chemical compositions of each extract were also determined via GC-Mass. Behavioral changes were studied via passive avoidance and Morris water maze in Aβ-induced model of Alzheimer's disease. Catalase (CAT) and superoxide dismutase (SOD) determination were also done on rats' hippocampus.

RESULTS: The results showed that seed Eth extract has a high level of TPC and radical scavenging activity. However, this extract had surprisingly no effect on memory and CAT and SOD activities. In contrast, fruit Aq and Eth extracts (containing furfurals as major compounds) inhibited memory impairment (P 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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