Affiliations 

  • 1 Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, 599489, Singapore; Department of Biomedical Engineering, School of Science and Technology, SIM University, 599491, Singapore; Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603, Malaysia
  • 2 Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, 599489, Singapore. Electronic address: mkm2@np.edu.sg
  • 3 Department of Electronics and Computer Engineering, Ngee Ann Polytechnic, 599489, Singapore
  • 4 Department of Electronics and Telecommunication, St. Francis Institute of Technology, Mumbai 400103, India
  • 5 Department of Ophthalmology, Kasturba Medical College, Manipal 576104, India
  • 6 National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 308433, Singapore
Comput Biol Med, 2016 06 01;73:131-40.
PMID: 27107676 DOI: 10.1016/j.compbiomed.2016.04.009

Abstract

Age-related Macular Degeneration (AMD) affects the central vision of aged people. It can be diagnosed due to the presence of drusen, Geographic Atrophy (GA) and Choroidal Neovascularization (CNV) in the fundus images. It is labor intensive and time-consuming for the ophthalmologists to screen these images. An automated digital fundus photography based screening system can overcome these drawbacks. Such a safe, non-contact and cost-effective platform can be used as a screening system for dry AMD. In this paper, we are proposing a novel algorithm using Radon Transform (RT), Discrete Wavelet Transform (DWT) coupled with Locality Sensitive Discriminant Analysis (LSDA) for automated diagnosis of AMD. First the image is subjected to RT followed by DWT. The extracted features are subjected to dimension reduction using LSDA and ranked using t-test. The performance of various supervised classifiers namely Decision Tree (DT), Support Vector Machine (SVM), Probabilistic Neural Network (PNN) and k-Nearest Neighbor (k-NN) are compared to automatically discriminate to normal and AMD classes using ranked LSDA components. The proposed approach is evaluated using private and public datasets such as ARIA and STARE. The highest classification accuracy of 99.49%, 96.89% and 100% are reported for private, ARIA and STARE datasets. Also, AMD index is devised using two LSDA components to distinguish two classes accurately. Hence, this proposed system can be extended for mass AMD screening.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.