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Repurposing Antimalarials to Tackle the COVID-19 Pandemic

Krishna S 1 , Augustin Y 2 , Wang J 3 , Xu C 4 , Staines HM 2 , Platteeuw H 5 Show all authors , Kamarulzaman A 6 , Sall A 7 , Kremsner P 8

Affiliations 

  • 1 Centre for Diagnostics and Antimicrobial Resistance, Institute for Infection and Immunity, St George's University of London, London, UK; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Tübingen, Germany. Electronic address: s.krishna@sgul.ac.uk
  • 2 Centre for Diagnostics and Antimicrobial Resistance, Institute for Infection and Immunity, St George's University of London, London, UK
  • 3 Artemisinin Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China; Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China; Department of Biological Sciences, National University of Singapore, 117543, Singapore
  • 4 Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China
  • 5 Avivia BV, Nijmegen, The Netherlands
  • 6 Faculty of Medicine, University of Malaya, Kuala Lumpar, Malaysia
  • 7 Institut Pasteur de Dakar, 36 Avenue Pasteur, B.P. 220 Dakar, Senegal
  • 8 Institut für Tropenmedizin, Universitätsklinikum Tübingen, Tübingen, Germany; Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon
Trends Parasitol, 2021 01;37(1):8-11.
PMID: 33153922 DOI: 10.1016/j.pt.2020.10.003

Abstract

Artemisinin-based combination therapies (ACTs) have demonstrated in vitro inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Artemisinins have also shown anti-inflammatory effects, including inhibition of interleukin-6 (IL-6) that plays a key role in the development of severe coronavirus disease 2019 (COVID-19). There is now sufficient evidence for the effectiveness of ACTs, and in particular artesunate/pyronaridine, to support clinical studies for COVID-19 infections.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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