• 1 Department of Fundamental and Applied Sciences, Universiti Teknologi PETRONAS, Malaysia, Seri Iskandar, Perak 32610, Malaysia
  • 2 Department of Physics, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia
  • 3 ImViA EA 7535, Team IFTIM, Université de Bourgogne, 21000 Dijon, France
  • 4 Department of Physics and Astronomy, University of Tennessee, 401 Nielsen Physics Building and Joint Institute for Materials Research 1408 Circle Drive Room 219 2641 Osprey Way, Knoxville, TN 37996, USA
  • 5 Physics Department, College of Science, Al-Imam Muhammad Ibn Saud Islamic University, P.O. Box 5701, Riyadh 11432, Saudi Arabia
  • 6 Radiology and Medical Imaging Department, College of Applied Medical Sciences Prince Sattam bin Abdulaziz University, P.O. Box 422, Alkharj 11942, Saudi Arabia
Polymers (Basel), 2020 Nov 20;12(11).
PMID: 33233844 DOI: 10.3390/polym12112750


This work reports the use of a ternary composite that integrates p-Toluene sulfonic acid doped polyaniline (PANI), chitosan, and reduced graphene oxide (RGO) as the active sensing layer of a surface plasmon resonance (SPR) sensor. The SPR sensor is intended for application in the non-invasive monitoring and screening of diabetes through the detection of low concentrations of acetone vapour of less than or equal to 5 ppm, which falls within the range of breath acetone concentration in diabetic patients. The ternary composite film was spin-coated on a 50-nm-thick gold layer at 6000 rpm for 30 s. The structure, morphology and chemical composition of the ternary composite samples were characterized by FTIR, UV-VIS, FESEM, EDX, AFM, XPS, and TGA and the response to acetone vapour at different concentrations in the range of 0.5 ppm to 5 ppm was measured at room temperature using SPR technique. The ternary composite-based SPR sensor showed good sensitivity and linearity towards acetone vapour in the range considered. It was determined that the sensor could detect acetone vapour down to 0.88 ppb with a sensitivity of 0.69 degree/ppm with a linearity correlation coefficient of 0.997 in the average SPR angular shift as a function of the acetone vapour concentration in air. The selectivity, repeatability, reversibility, and stability of the sensor were also studied. The acetone response was 87%, 94%, and 99% higher compared to common interfering volatile organic compounds such as propanol, methanol, and ethanol, respectively. The attained lowest detection limit (LOD) of 0.88 ppb confirms the potential for the utilisation of the sensor in the non-invasive monitoring and screening of diabetes.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.