International stroke genetics consortium recommendations for studies of genetics of stroke outcome and recovery

Lindgren AG 1 , Braun RG 2 , Juhl Majersik J 3 , Clatworthy P 4 , Mainali S 5 , Derdeyn CP 6 Show all authors , Maguire J 7 , Jern C 8 , Rosand J 9 , Cole JW 10 , Lee JM 11 , Khatri P 12 , Nyquist P 13 , Debette S 14 , Keat Wei L 15 , Rundek T 16 , Leifer D 17 , Thijs V 18 , Lemmens R 19 , Heitsch L 11 , Prasad K 20 , Jimenez Conde J 21 , Dichgans M 22 , Rost NS 9 , Cramer SC 23 , Bernhardt J 18 , Worrall BB 24 , Fernandez-Cadenas I 25 , International Stroke Genetics Consortium

Affiliations 

  • 1 Department of Clinical Sciences Lund, Neurology, 5193-->Lund University, Lund, Sweden
  • 2 Department of Neurology, University of Maryland, Baltimore, MD, USA
  • 3 Department of Neurology, University of Utah, Salt Lake City, UT, USA
  • 4 Department of Neurology, North Bristol NHS Trust, Bristol, UK
  • 5 Department of Neurology, 2647-->The Ohio State University, Columbus, OH, USA
  • 6 Department of Radiology, University of Iowa, Iowa City, IA, USA
  • 7 Faculty of Health, University of Technology Sydney, Ultimo, NSW, Australia
  • 8 Department of Laboratory Medicine, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden
  • 9 Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
  • 10 Neurology Service, Baltimore Veterans Affairs Medical Center, Baltimore, MD, USA
  • 11 Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
  • 12 Department of Neurology and Rehabilitation Sciences, University of Cincinnati, Cincinnati, OH, USA
  • 13 Neurology, Anesthesiology/Critical Care Medicine, Neurosurgery, and General Internal Medicine, 1500-->Johns Hopkins School of Medicine, Baltimore, MD, USA
  • 14 Bordeaux Population Health, Inserm U1219, University of Bordeaux, Bordeaux, France
  • 15 Department of Biological Science, Faculty of Science, Universiti Tunku Abdul Rahman, Perak, Malaysia
  • 16 Department of Neurology, 12235-->University of Miami Miller School of Medicine, Miami, FL, USA
  • 17 Department of Neurology, Weill Cornell Medicine, New York, NY, USA
  • 18 Stroke Theme, Florey Institute of Neuroscience and Mental Health, Melbourne, Vic, Australia
  • 19 Department of Neuroscience, University of Leuven, Leuven, Belgium
  • 20 Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
  • 21 Neurology Department, Neurovascular Research Group, Institut Hospital del Mar d'Investigació Mèdica, Barcelona, Spain
  • 22 Institute for Stroke and Dementia Research, University Hospital, LMU, Munich, Germany
  • 23 Department of Neurology, UCLA, Los Angeles, CA, USA
  • 24 Department of Neurology, University of Virginia, Charlottesville, VA, USA
  • 25 Stroke Pharmacogenomics and Genetics Group, Sant Pau Biomedical Research Institute, Barcelona, Spain
Int J Stroke, 2021 Apr 26.
PMID: 33739214 DOI: 10.1177/17474930211007288

Abstract

Numerous biological mechanisms contribute to outcome after stroke, including brain injury, inflammation, and repair mechanisms. Clinical genetic studies have the potential to discover biological mechanisms affecting stroke recovery in humans and identify intervention targets. Large sample sizes are needed to detect commonly occurring genetic variations related to stroke brain injury and recovery. However, this usually requires combining data from multiple studies where consistent terminology, methodology, and data collection timelines are essential. Our group of expert stroke and rehabilitation clinicians and researchers with knowledge in genetics of stroke recovery here present recommendations for harmonizing phenotype data with focus on measures suitable for multicenter genetic studies of ischemic stroke brain injury and recovery. Our recommendations have been endorsed by the International Stroke Genetics Consortium.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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