Antimicrobial and self-crosslinking potential of experimentally developed dioctadecyldimethyl ammonium bromide and riboflavin dentin adhesive

Daood U 1 , Malik AA 2 , Ilyas MS 2 , Ahmed A 2 , Qasim SSB 3 , Banavar SR 4 Show all authors , Khan AS 5 , Kuan EKS 1 , Bilal S 6 , Matinlinna J 7 , Seow LL 1

Affiliations 

  • 1 Clinical Dentistry, Faculty of Dentistry, International Medical University Kuala Lumpur, Kuala Lumpur, Malaysia
  • 2 Department of Oral Biology, Post Graduate Medical Institute, Lahore, Pakistan
  • 3 Department of Bioclinical Sciences, Faculty of Dentistry, Kuwait University, Safat, Kuwait
  • 4 Oral Diagnostic and Surgical Sciences, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia
  • 5 Department of Restorative Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
  • 6 Department of Children and Community Oral Health, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia
  • 7 Dental Materials Science, Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China
J Biomed Mater Res A, 2021 Nov;109(11):2392-2406.
PMID: 34018311 DOI: 10.1002/jbm.a.37221

Abstract

The aim of the study is to investigate a new formulation, based on dioctadecyldimethyl ammonium-bromide (QA) and riboflavin (RF), combining antimicrobial activities and protease inhibitory properties with collagen crosslinking without interference to bonding capabilities in a rabbit model. Quaternary ammonium riboflavin (QARF) experimental adhesives modified with dioctadecyldimethyl ammonium-bromide and riboflavin were bonded (0.5/1.0/2.0%) to rabbit dentin to investigate for pulpal-histology, interfacial-morphology, transmission electron microscopy, mechanical properties, collagen crosslinking, micro-Raman analysis, antimicrobial, and anti-protease activities. Collagen type-I molecules were generated using molecular-docking. Odontoblasts appeared with normal histology, were seen in controls with no inflammatory cells detected in 0.5% specimens at day 7 and mild inflammatory response at day 30. In QARF 2.0%, inflammatory cells were not detected at day 7 and 30 (p 

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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